# OSUCCC CUSP2CT

> **NIH NIH U01** · OHIO STATE UNIVERSITY · 2022 · $708,750

## Abstract

PROJECT SUMMARY
The overall goal of The Ohio State University (OSU) Connecting Underrepresented Populations to Clinical Trials
(CUSP2CT) is to increase the referral and accrual of racial/ethnic minorities to NCI's National Clinical Trials
Network (NCTN) prevention/control and treatment trials at the OSU Comprehensive Cancer Center (OSUCCC).
This research is grounded in the socioecologic model developed by the Centers for Population Health and Health
Disparities (Warnecke, et al. Am J Public Health 2008) and utilizes the theoretical model, Accrual to Clinical
Trials (Paskett, et al. Clin Adv Hematol Oncol 2003). The OSUCCC serves the catchment area of the state of
Ohio where over 95% of our patients with cancer reside. Working closely with the OSUCCC Center for Cancer
Health Equity (CCHE), OSUCCC National Outreach Network, community partner organizations, community
providers in the OSUCCC referral area, James Hospital Network sites, NCI Community Oncology Research
Program (NCORP) sites in Ohio, and the OSUCCC Clinical Trials Office, our goal will be accomplished by
completing the following specific aims: 1) Conduct a baseline assessment of referral patterns and accrual of
racial and ethnic minorities to clinical trials at OSUCCC by cancer disease group (breast, gastrointestinal,
genitourinary, thoracic, hematologic, and others) and examine factors at the system (i.e., eligible clinical trial
protocol, clinic context and culture), provider (trial discussed with patient), and patient level (agreed or refused
participation) that influence referral and accrual (Phase I); 2) Implement a multi-level intervention in a stepped
wedge design in referring practices in 9 counties with high counts of minority cancer cases in the OSUCCC
catchment area using the Accrual to Clinical Trials framework (Paskett, et al. Clin Adv Hematol Oncol 2003), in
Phase II. The intervention will include an outreach component, directed at community members and community
practices, and an in-reach component, involving patients, providers, and the hospital system (at both referral
centers and the OSUCCC) that directly addresses problems identified in Phase I; and 3) to evaluate the impact
of the intervention on referral (primary outcome) and accrual patterns (secondary outcomes) in Phase III to
clinical trials. Both qualitative and quantitative methods will be used. Dissemination of the key findings of our
multi-level intervention is a high priority of this project.

## Key facts

- **NIH application ID:** 10540023
- **Project number:** 1U01CA274999-01
- **Recipient organization:** OHIO STATE UNIVERSITY
- **Principal Investigator:** CHERYL T. LEE
- **Activity code:** U01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $708,750
- **Award type:** 1
- **Project period:** 2022-09-12 → 2027-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10540023

## Citation

> US National Institutes of Health, RePORTER application 10540023, OSUCCC CUSP2CT (1U01CA274999-01). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10540023. Licensed CC0.

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