ABSTRACT Support is requested for a Keystone Symposia conference entitled Protein-RNA Interactions, organized by Drs. Gene Yeo, Wendy Gilbert and Lori Passmore. The conference will be held in Vancouver, Canada from January 29- February 1, 2023. Ribonucleic acid (RNA) binding proteins (RBPs) are a major category of regulators encoded by more than two thousand human genes. Over the last few years, millions of protein-RNA interactions in a myriad of cellular contexts have been measured by increasingly scalable technologies, providing opportunity for deeper connections with genetics and disease. In parallel, stunning breakthroughs in microscopy and structural methods have revealed fundamental insights into protein-RNA interactions. This conference addresses growing excitement from both the basic and translational life sciences community in imagining protein-RNA interactions as a treasure trove of new biology and drug targets. This conference is unique in that it will provide a forum to assemble multi-disciplinary leaders in various themes in the RNA community to cross- fertilize emerging ideas in fundamental protein-RNA science. Other sessions will introduce a diversity of newcomers to the newest methods and results in the field and introduce and identify new targets and modalities for therapeutic opportunities. Finally, this conference will be held jointly with the Keystone Symposia conference on Biomolecular Condensates which is a natural collaboration as RNA binding proteins play major roles in condensation of protein-RNA/DNA interactions. Participants at both conferences will be able to network and develop new collaborations through shared sessions and meals.