PROJECT SUMMARY Bone fractures occur in more than 25 million Americans per year, and a significant percentage of those fractures fail to heal. Fractures that show delayed or failed progression to heal account for the majority of patient disability and costs. Thus, there is an urgent need to better understand the biology of bone healing, and to use that knowledge to develop new diagnostics and therapeutics. We are seeking support for the 17th Biennial conference of the International Section of Fracture Repair (ISFR). In 2017, the ISFR was incorporated as a section within the Orthopaedic Research Society (ORS), thereby leveraging the outreach of the largest scientific organization in the world dedicated to orthopaedic research. The ISFR is dedicated to the advancement and exchange of the most current scientific ideas and research findings on fracture repair and its application to the improvement of patient care. Our mission is be the premier forum to integrate and present cutting-edge ideas related to clinical, translational, and basic science research of fracture healing. With an organizational theme of “Transdisciplinary Science”, sessions will focus on the newest understanding of mechanobiology from the cellular to patient scale and its role in bone repair; commercial considerations for device development and translating ideas from bench to market; and personalized regenerative therapies and associated advanced technologies (i.e., therapeutics, organ-on-a-chip, interplay with the immune system). In an effort to increase clinical participation, the Biennial ISFR Meeting will be held just prior to the International Combined Orthopaedic Research Societies (ICORS) 30th Anniversary World Congress. The ICORS World Congress program is co-hosted by the European ORS (EORS), British ORS (BORS), and AO Research Institute Davos. To catalyze cross-pollination between the ISFR and these societies, the second day of our meeting (September 7th) has been designed as a clinical bridge day where both ISFR and ICORS members can attend. In total, we will have 2 invited keynote speakers, 20 invited session speakers, and 15 abstract-selected podium presentations. We anticipate an additional 30-40 abstracts selected as posters. The meeting will present the most up to date research on fracture healing basic biology, translational research, and prospective clinical studies. The Program Committee is highly focused on fostering an inclusive environment. Surgeons, biologists, engineers, and policy makers will attend the meeting and be drawn from academia, government, and industry. A variety of activities will be focused on career development and networking for trainees in the bone healing field.