# Temperature and metabolic compensation mechanisms in a circadian clock system

> **NIH NIH R35** · UNIVERSITY OF CALIFORNIA, MERCED · 2023 · $378,518

## Abstract

Project Summary/Abstract
Circadian clocks are intracellular enzymatic systems that provide a biochemical
representation of local time with profound consequences to health across diverse
organisms. Unlike most enzymes, biological clocks need to be insensitive to a range
of physiological temperatures and cellular energy levels so that organisms can
anticipate dawn and dusk reliably. However, the mechanisms by which circadian
clocks in any organism achieve insensitivity to temperature (i.e., temperature
compensation) and cellular energy levels (i.e., metabolic compensation) are far from
understood. Therefore, the overall vision of the LiWang lab for the next five years is to
elucidate the mechanisms of temperature compensation and metabolic
compensation in the circadian clock of cyanobacteria. Over the past 20 years, we
have made many impactful discoveries on mechanism of the cyanobacterial clock
and developed innovative methodologies and tools along the way. Thus, we are very
well positioned to succeed at filling critical gaps in knowledge in the field of
biological timekeeping. A major expected outcome of the work proposed here is a
detailed cause-and-effect model linking clock protein behavior and interactions to
temperature and metabolic compensation phenotypes in vivo.

## Key facts

- **NIH application ID:** 10544006
- **Project number:** 5R35GM144110-02
- **Recipient organization:** UNIVERSITY OF CALIFORNIA, MERCED
- **Principal Investigator:** Andy LiWang
- **Activity code:** R35 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2023
- **Award amount:** $378,518
- **Award type:** 5
- **Project period:** 2022-01-01 → 2026-12-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10544006

## Citation

> US National Institutes of Health, RePORTER application 10544006, Temperature and metabolic compensation mechanisms in a circadian clock system (5R35GM144110-02). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10544006. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*