# Cellular Imaging Core (CIC)

> **NIH NIH P50** · BOSTON CHILDREN'S HOSPITAL · 2022 · $1,416,000

## Abstract

ABSTRACT 
The Cellular Imaging Core (CIC) plays a pivotal role in the multidisciplinary research pipeline of IDDRC 
investigators at Boston Children’s Hospital and Harvard Medical School. Located within the Kirby Neurobiology 
Center of Boston Children’s Hospital, this shared microscopy facility offers researchers access to high-end and 
specialized microscopy and digital imaging approaches which they can harness to understand the underlying 
mechanisms and structural changes associated with neurodevelopmental disorders. The Core offers widefield, 
confocal (multiphoton, laser-scanning, spinning disk) and super-resolution (stimulated emission depletion, 
STED) microscopes for high resolution subcellular localization of proteins of interest, for tracking live cells over 
prolonged periods of time, and for monitoring populations of cells in vivo in an awake, behaving animal. These 
instruments are accompanied with access to image analysis workstations, and importantly, to an extensive 
educational program that trains researchers one-on-one on the capabilities and limitations of each instrument 
and software package used. Core staff can also collaborate closely with IDDRC researchers in core-assisted 
projects to design, optimize and implement custom designed experiments or analysis approaches. Additionally, 
the Core offers Instrumentation and Technology Courses to inform the scientific community about what is new 
for state-of-the-art microscopy, to provide interactive, hands-on workshops on image acquisition, analysis and 
processing and to address issues in robustness with these imaging methods. Through these interactions with 
researchers, the Core identifies and obtains new equipment and technology that is relevant to our researchers. 
Taken together, here the CIC proposes a comprehensive program of collaboration with IDDRC investigators 
and other IDDRC Cores to lower the barrier for laboratories to incorporate novel and transformative 
microscopy technologies that elevate and accelerate our understanding of normal and pathological neural 
development, plasticity and function.

## Key facts

- **NIH application ID:** 10545300
- **Project number:** 5P50HD105351-02
- **Recipient organization:** BOSTON CHILDREN'S HOSPITAL
- **Principal Investigator:** Hisashi Umemori
- **Activity code:** P50 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $1,416,000
- **Award type:** 5
- **Project period:** 2021-07-22 → 2026-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10545300

## Citation

> US National Institutes of Health, RePORTER application 10545300, Cellular Imaging Core (CIC) (5P50HD105351-02). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10545300. Licensed CC0.

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