# Shim System for Removing ICD Artifacts from Patient Cardiac MR Images

> **NIH NIH R41** · MIRTECH, INC. · 2022 · $309,942

## Abstract

Project Abstract
 1.4 million people in the US (2021) have implanted cardioverter-defibrillators (ICDs) of which ~50% will
require an MRI scan in their lifetime. All ICDs generate large artifacts in MRI such as signal-voids in cardiac MR
(cMR) images, which frequently occur in important pathological (infarcted) regions. Reliable diagnosis of
ventricular tachycardia, premature ventricular contraction and myocarditis using cMR is therefore prevented, as
well as MR-guided therapy of these potentially life-threatening diseases. The scanner’s own shim coils cannot
correct these large inhomogeneities, so powerful dedicated resistive shim coils are required.
 It is proposed that a Cardiac Shim System (CSS), consisting of a mechanical frame for accurate shim-coil
placement, a shim coil, a programmable power supply, electromagnetic filtering circuits, shim-coil placement
optimization software, and system-use protocols can be used to precisely reduce artifacts in a user-determined
region of the heart. The innovative CSS design does not interact with, and is not acted upon by, the rf coils and
the gradient coils of the scanner, maintaining the scanner’s specified performance. Furthermore, the magnetic
forces acting upon the CSS are balanced, permitting the shim coil to be moved freely within the MRI scanner
bore and maximizing patient safety.
 Aim 1 of this Phase I STTR project is to develop a commercial prototype (V2), based upon the initial proof-
of-concept system (V1), to be used on a Siemens 1.5T MRI scanner at JHU. This includes refinements in shim
coil design, software reconstruction, protocol development, and the development of a motorized positioning
system. In Aim 2, it is proposed, to test this novel system quantitatively using 5 infarcted swine and 6 human
volunteers to demonstrate CSS effectiveness in performing cMR safely using standard cardiac MRI protocols
such as LGE and cine. Future Phase 2 efforts will pursue clinical testing to prepare for submission to the FDA
for regulatory clearance.

## Key facts

- **NIH application ID:** 10546727
- **Project number:** 1R41HL166053-01
- **Recipient organization:** MIRTECH, INC.
- **Principal Investigator:** Yue Chen
- **Activity code:** R41 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $309,942
- **Award type:** 1
- **Project period:** 2022-09-15 → 2024-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10546727

## Citation

> US National Institutes of Health, RePORTER application 10546727, Shim System for Removing ICD Artifacts from Patient Cardiac MR Images (1R41HL166053-01). Retrieved via AI Analytics 2026-06-01 from https://api.ai-analytics.org/grant/nih/10546727. Licensed CC0.

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