# Investigations of Pathologic Remodeling Using Pediatric Heart Failure Serum

> **NIH NIH K24** · UNIVERSITY OF COLORADO DENVER · 2023 · $106,674

## Abstract

Abstract
Heart failure (HF) is one of the leading causes of hospitalization in the United States and is
associated with substantial adverse effects on quality of life as well as a mortality rate on the
order of the most lethal forms of cancer. Treatment for adults with HF varies from well-
established neurohormonal inhibitors to device therapy. However, despite the demonstrated
benefits of current therapy, the societal and economic burdens of HF are increasing. In pediatric
HF from dilated cardiomyopathy (DCM) five-year freedom from death or transplant remains low,
ranging from 54%-63%. This suggests that there are underlying myocardial cellular
mechanisms uniquely regulated in children with HF. Irrespective of age or etiology of HF, new
therapies for HF are necessary to improve morbidity and mortality and decrease health care
costs.
The proposed studies will use meticulously preserved pediatric serum along with all relevant
clinical data, and are designed to integrate patient samples with an in vitro system that is a
surrogate for pathological changes observed in the myocardium. In addition, this award will
provide protected time for Dr. Sucharov to continue her successful mentorship of junior faculty
and fellows trainees. The translational aspect of this work will be relevant to MD fellows and
junior faculty, and will allow patient oriented research without risk to children with HF.

## Key facts

- **NIH application ID:** 10548138
- **Project number:** 5K24HL150630-04
- **Recipient organization:** UNIVERSITY OF COLORADO DENVER
- **Principal Investigator:** CARMEN C SUCHAROV
- **Activity code:** K24 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2023
- **Award amount:** $106,674
- **Award type:** 5
- **Project period:** 2019-12-01 → 2024-11-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10548138

## Citation

> US National Institutes of Health, RePORTER application 10548138, Investigations of Pathologic Remodeling Using Pediatric Heart Failure Serum (5K24HL150630-04). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10548138. Licensed CC0.

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