# Neonatal Seizure Registry Developmental Functional EValuation (NSR-DEV)

> **NIH NIH R01** · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2023 · $1,035,784

## Abstract

PROJECT SUMMARY
Neonatal seizures due to brain injury (acute symptomatic seizures) are associated with high risk of
neurodevelopmental disability in infancy. Although prognosis in early childhood is a critical question for parents
and providers, outcomes beyond infancy are largely unknown. Further, parents of infants with neonatal
seizures are at risk for mental health disorders, which can undermine their ability to care for a child with
medical complexity and may contribute to impaired child development. The proposed “Neonatal Seizure
Registry – Developmental functional EValuation (NSR-DEV)” study will test the central hypothesis that risk
factors for developmental disabilities can be identified in infancy and are modified by parent well-being.
This observational study will leverage the infrastructure of the 9 center Neonatal Seizure Registry, to which we
have recruited >300 children with acute symptomatic neonatal seizures (NCT02789176). With support for the
current proposal, this unique cohort will be available at ages 2-7 years to participate in annual validated parent-
reported developmental evaluations to characterize cognition, adaptive behavior, executive function, behavior,
epilepsy and cerebral palsy, as well as in-person, gold standard IQ testing with the WPPSI-IV at age 5 years.
Using neonatal clinical, EEG and MRI measures, as well as 3-month EEG, and longitudinal measures of parent
well-being, we will build robust models to predict developmental outcome in this high risk population.
We will test our hypotheses by pursuing the following specific aims: Aim 1a: Identify predictors of disability in
children with prior acute symptomatic neonatal seizures; Aim 1b: Examine risk factors for decline in adaptive
behavior in children with prior acute symptomatic neonatal seizures; Aim 2a: Determine whether parent well-
being (validated measures for symptoms of anxiety or depression, post-traumatic stress, and resilience) alters
the risk for disability among children with prior acute symptomatic neonatal seizures; Aim 2b: Determine
whether parent well-being alters the adaptive behavior trajectory in children with prior acute symptomatic
neonatal seizures; Aim 3: Build robust risk prediction models for childhood disability after neonatal seizures.
This innovative proposal will maintain an existing, multicenter cohort enrolled from US centers that employ
state-of-the-art technology for diagnosis and investigation of neonatal seizures, and targets research priorities
of parents and clinicians. This carefully designed study will provide novel, clinically-relevant answers to key
questions about long term outcomes in this highly vulnerable patient population. Results will inform the
subsequent design of neuromodulatory intervention studies and programs designed to optimize parent-related
factors with the goal of improving neurodevelopmental outcomes.

## Key facts

- **NIH application ID:** 10550229
- **Project number:** 5R01NS111166-04
- **Recipient organization:** UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- **Principal Investigator:** Hannah Cranley Glass
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2023
- **Award amount:** $1,035,784
- **Award type:** 5
- **Project period:** 2020-03-15 → 2026-02-28

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10550229

## Citation

> US National Institutes of Health, RePORTER application 10550229, Neonatal Seizure Registry Developmental Functional EValuation (NSR-DEV) (5R01NS111166-04). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10550229. Licensed CC0.

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