# A Normal Paradigm to Monitor Perinatal Asphyxia Using A Combined Ultrasound-Neuromodulation and Photoacoustic-Imaging Device

> **NIH NIH R41** · BRIMROSE TECHNOLOGY CORPORATION · 2022 · $300,000

## Abstract

PROJECT SUMMARY
 The Brimrose Technology Corporation and partner, The Johns Hopkins University, propose
using non-invasive ultrasound neuromodulation to identify hypoxic-ischemic encephalopathy (HIE) in
newborns to reduce death and lifelong brain injury. HIE is the leading cause of neonatal death and
impacts 2-6 of every 1,000 live births in the developed world. Our goal is to investigate and demonstrate
the effect of graded hypoxia and repeated oxygen/glucose deprivation on neural response using
ultrasound modulation. We will then develop and validate an ultrasound-neuromodulation coupled with
photoacoustic-imaging device prototype to monitor neonatal brain injury. This device will be used for
early diagnosis of HIE to enable timely intervention, which minimizes long-term disability. The two
organizations have established a strong research team and joint operating lab at Hopkins to develop
this system. Due to various limitations of current methods, there is an urgent need for an early HIE
diagnostic kit to enable prompt therapeutic interventions. There are no early diagnostic procedures or
devices available in the clinic for HIE. Hence, our proposal addresses a critical unmet need.

## Key facts

- **NIH application ID:** 10552231
- **Project number:** 1R41EB033751-01
- **Recipient organization:** BRIMROSE TECHNOLOGY CORPORATION
- **Principal Investigator:** Emad M Boctor
- **Activity code:** R41 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $300,000
- **Award type:** 1
- **Project period:** 2022-09-23 → 2024-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10552231

## Citation

> US National Institutes of Health, RePORTER application 10552231, A Normal Paradigm to Monitor Perinatal Asphyxia Using A Combined Ultrasound-Neuromodulation and Photoacoustic-Imaging Device (1R41EB033751-01). Retrieved via AI Analytics 2026-05-28 from https://api.ai-analytics.org/grant/nih/10552231. Licensed CC0.

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