# The Jackson Laboratory Senescence Tissue Mapping Center (JAX-Sen TMC) - Biological Analysis Core

> **NIH NIH U54** · JACKSON LABORATORY · 2022 · $828,695

## Abstract

PROJECT SUMMARY/ABSTRACT BIOLOGICAL ANALYSIS CORE
The primary objective of the Biological Analysis Core (BAC) of the JAX-Sen mouse Tissue Mapping Center
(TMC) is to provide high resolution state-of-the-art molecular, cellular, and tissue-level characterization of
mouse tissues for the purpose of identifying robust biomarkers of senescence and, from this, build tissue-
specific atlases at the cellular, microenvironment, and secretome levels. The BAC will generate high resolution,
high content, high-throughput biomolecular data to generate comprehensive maps of cellular senescence in six
primary mouse tissues, across two mouse model systems - a large cohort of Diversity Outbred (DO) mice
representing genetic diversity and the required C57BL/6 strain. To achieve these goals, the BAC will 1)
develop and apply a pipeline to generate unbiased, high-quality, high-resolution, and high-throughput datasets
to discover biomarkers of senescence, 2) develop a high-throughput, high-content tissue phenotyping pipeline
and apply this to a cohort of 400 DO mice, 3) generate high biomolecular content, multi-parameter spatial
measurements on 2D serial sections to enable 3D tissue reconstruction, and 4) leverage p16/p21 reporter
mouse lines to comprehensively profile senescent cells sorted from aged mice. Once complete, this project will
have generated multi-scale, multi-dimensional maps of senescence cells within six mouse tissues from control
and senolytics treated tissues, information that will be critical to optimize and guide future senolytic
interventions in human trials.

## Key facts

- **NIH application ID:** 10552967
- **Project number:** 1U54AG079753-01
- **Recipient organization:** JACKSON LABORATORY
- **Principal Investigator:** Paul Robson
- **Activity code:** U54 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $828,695
- **Award type:** 1
- **Project period:** 2022-08-15 → 2026-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10552967

## Citation

> US National Institutes of Health, RePORTER application 10552967, The Jackson Laboratory Senescence Tissue Mapping Center (JAX-Sen TMC) - Biological Analysis Core (1U54AG079753-01). Retrieved via AI Analytics 2026-05-27 from https://api.ai-analytics.org/grant/nih/10552967. Licensed CC0.

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