# Core C

> **NIH NIH U54** · YALE UNIVERSITY · 2022 · $457,460

## Abstract

SUMMARY – Core C: Data Analysis Core (BAC)
The Data Analysis Core (DAC) will build on available computational infrastructure to fulfill all the needs for
advanced data analysis and informatics of Yale murine-TMC. It will also support data storage & sharing,
metadata management & referencing, integration & query via a web portal, and rigorous statistical analyses to
accomplish the Center's missions. The DAC is led by Dr. Kluger, who provides prominent expertise in
bioinformatics and computational analysis of multi-dimensional data. He as an extensive track record of
methodology development and led major efforts in analyzing genomics, proteomics, and high-plex imaging data
in NIH consortia. Co-lead Gershkovich, Director of Yale Pathology Informatics infrastructure, software
development, and system management, will provide important expertise in building frameworks and portals for
integrating biospecimen meta data with biological analysis data from multiple modalities including omics and
images. Core C will be responsible for 1) data Processing – to set up a set of multiscale and multimodal data
processing pipelines and quality assurance protocols. 2) Data Analysis – to establish an integrated single-cell &
spatial data analysis workflow to detect different types of senescence biomarker signatures. 3) Data Analysis –
to establish an integrated single-cell & spatial data analysis workflow to detect different types of senescence
biomarker signatures.4) Consortium Coordination – to work with the CODCC and other TMCs to develop data
models, databases, design and visualization tools, and create new interoperability mechanisms and platforms.
These are highly valuable next-generation biomedical data resources for NIH TMC consortia and the broader
community of basic research and Geroscience .

## Key facts

- **NIH application ID:** 10553035
- **Project number:** 1U54AG079759-01
- **Recipient organization:** YALE UNIVERSITY
- **Principal Investigator:** Yuval Kluger
- **Activity code:** U54 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $457,460
- **Award type:** 1
- **Project period:** 2022-08-02 → 2026-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10553035

## Citation

> US National Institutes of Health, RePORTER application 10553035, Core C (1U54AG079759-01). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10553035. Licensed CC0.

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