# Analysis of mouse models of premature glial senescence

> **NIH NIH R21** · GEORGETOWN UNIVERSITY · 2023 · $195,000

## Abstract

Project Summary
CNS glial cells, including oligodendrocytes, astrocytes and microglia, regulate neuronal function. Although much is known
about their importance in the developing and adult CNS, a gap in knowledge remains with regards to how aged glia
contribute to remyelination failure and neurodegeneration. This is particularly relevant to age related neurodegenerative
disorders, such as secondary progressive multiple sclerosis (MS), Alzheimer’s disease (AD), and Parkinson’s disease (PD)
in which glial dysfunction and chronic inflammation within the CNS, are common features. In order to fully understand the
impact of aged glia on CNS function, the goal of this project is to characterize novel models of CNS glial senescence in
mice and examine their impact on CNS function and repair.

## Key facts

- **NIH application ID:** 10554278
- **Project number:** 5R21AG072327-02
- **Recipient organization:** GEORGETOWN UNIVERSITY
- **Principal Investigator:** Jeffrey K Huang
- **Activity code:** R21 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2023
- **Award amount:** $195,000
- **Award type:** 5
- **Project period:** 2022-02-01 → 2024-01-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10554278

## Citation

> US National Institutes of Health, RePORTER application 10554278, Analysis of mouse models of premature glial senescence (5R21AG072327-02). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10554278. Licensed CC0.

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