# Maintenance and Incidence of ME/CFS following Mono

> **NIH NIH R01** · DE PAUL UNIVERSITY · 2022 · $200,734

## Abstract

Abstract
This proposal would allow us to compare EBV and SARS-CoV-2 immune markers and metabolomics on the
samples from our unique data sets. Immune and metabolomic analyses are interesting discovery tools and an
important aspect of the integrative approach we will use, with their broad and flexible potential for studying
post-viral fatigue. We have also shown that college students with post-IM ME/CFS have an inflammatory
profile, even at baseline, different from those who recover from IM (Jason, Cotler, et al., 2021). In addition,
metabolomics has emerged as a novel tool for analyzing post-viral fatigue. Multiple studies have reported
detectable changes in metabolic pathways related to energy production, amino acids, nucleotides, nitrogen,
lipids, and neurotransmitters in patients with post-viral fatigue (Armstrong et al., 2014; Germain, Ruppert,
Levine, & Hanson., 2017; Nagy-Szakal et al., 2018; Naviaux et al., 2016). Our study of immunology and
metabolomics hopes to identify possible biosignatures for PASC and ME/CFS. Our primary aims are to
determine immunologic and metabolomic risk factors for the development of PASC following SARS CoV-2
infection and ME/CFS following IM. We hypothesize that altered host immune and metabolomic profiles will be
associated with post-viral fatigue following primary EBV and SARS-CoV-2 infection, in contrast to healthy
controls. In addition, qualitative in-depth interviews will explore perceptions of the following: major life
changes, fluctuations in employment status, changes in somatic symptoms, changes in coping strategies,
changes in physical and mental status, and the evolution of support systems, to determine which if any of
these factors are also important for the development and maintenance of PASC and ME/CFS.

## Key facts

- **NIH application ID:** 10554994
- **Project number:** 3R01NS111105-03S1
- **Recipient organization:** DE PAUL UNIVERSITY
- **Principal Investigator:** Leonard A Jason
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $200,734
- **Award type:** 3
- **Project period:** 2020-01-01 → 2024-11-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10554994

## Citation

> US National Institutes of Health, RePORTER application 10554994, Maintenance and Incidence of ME/CFS following Mono (3R01NS111105-03S1). Retrieved via AI Analytics 2026-06-14 from https://api.ai-analytics.org/grant/nih/10554994. Licensed CC0.

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