# AMP-AD Brain Proteomic Network Enhancement, Validation, and Translation into CSF Biomarkers

> **NIH NIH U01** · EMORY UNIVERSITY · 2022 · $391,250

## Abstract

Project Summary
The overarching goal of the AMP-AD 2.0 research plan is to generate and analyze RNAseq, whole genome
sequencing (WGS) and proteomic data from the dorsolateral prefrontal cortex (DLPFC) and conduct comparative
studies using the data generated on this project with the AMP-AD RNAseq, WGS and proteomic data generated
on Caucasian cohorts in AMP-AD 1.0. In addition to generating genomic and proteomic data on diverse post-
mortem brain samples, this project will also generate WGS and proteomic data on CSF and matching plasma
samples collected from additional 325 diverse well-phenotyped individuals (Emory Cohorts). The 325
CSF/plasma samples (including ~146 African Americans) are from individuals with cognitive data. This
supplement will support the WGS from these 325 participants that will be integrated with additional
proteomic data (CSF and plasma).

## Key facts

- **NIH application ID:** 10557388
- **Project number:** 3U01AG061357-04S3
- **Recipient organization:** EMORY UNIVERSITY
- **Principal Investigator:** ALLAN I LEVEY
- **Activity code:** U01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $391,250
- **Award type:** 3
- **Project period:** 2018-09-30 → 2023-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10557388

## Citation

> US National Institutes of Health, RePORTER application 10557388, AMP-AD Brain Proteomic Network Enhancement, Validation, and Translation into CSF Biomarkers (3U01AG061357-04S3). Retrieved via AI Analytics 2026-06-14 from https://api.ai-analytics.org/grant/nih/10557388. Licensed CC0.

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