# Gender Differences in Physical Activity Among Patients with Implantable Cardioverter Defibrillators (ICDs)

> **NIH NIH K23** · UNIV OF NORTH CAROLINA CHAPEL HILL · 2022 · $54,000

## Abstract

PROJECT SUMMARY/ABSTRACT
This career development award will facilitate Dr. Rosman’s transition to an independent research career and
support her becoming a future leader in women’s cardiovascular health. It will equip her with the knowledge,
tools, and experiences needed to develop patient-centered interventions to improve cardiovascular and quality
of life outcomes in women with cardiac arrhythmias and implantable cardioverter-defibrillators (ICDs). These
long-term goals are supported by a 5-year training plan to develop expertise in: (1) chronic disease
epidemiology and biostatistics; (2) physical activity (PA) assessment and data analysis; (3) clinical trials; and
(4) technology-based interventions (mHealth). She has assembled a multidisciplinary team of mentors who are
experts in epidemiology, biostatistics, PA, cardiac electrophysiology, and technology-based (mHealth) clinical
trials to facilitate her transition to independence in a rich research environment. Dr. Rosman is a Clinical Health
Psychologist and a postdoctoral research fellow in Cardiovascular Behavioral Medicine at the Yale School of
Medicine. This proposal builds logically on her clinical background and prior research, which has focused on
functional status and quality of life outcomes in women with cardiovascular disease and patients with
arrhythmias.
 For the past 6 years, much of Dr. Rosman’s clinical work and research has focused on a subset of
arrhythmia patients with ICDs who have an elevated mortality risk due to physical inactivity. Women are among
the least active ICD patients and have an elevated risk for adverse outcomes, yet participation in traditional PA
interventions (e.g., cardiac rehabilitation) remains low. mHealth may offer an innovative and cost-effective
method to engage women with ICDs, collect detailed behavioral data (e.g., from built-in ICD accelerometer),
and integrate these data with patient-reported outcomes to provide targeted feedback in real-time and promote
behavior change. Yet the knowledge base upon which to build these interventions for ICD patients and tailor it
for women (e.g., gender differences in the patterns, predictors, and barriers to PA after ICD implant) is lacking.
Also lacking is the requisite data concerning levels of PA associated with lower mortality risk, gender
differences in these outcomes, and preferences for PA intervention(s). Dr. Rosman’s research plan will
address these critical gaps in knowledge using longitudinal ICD-accelerometer and EMR data from a large,
national sample of prospectively enrolled ICD patients. She will: AIM 1: examine gender differences in PA and
risk factors for inactivity after ICD implant; and AIM 2: examine associations between PA and mortality in these
patients. In AIM 3: she will conduct a survey of newly implanted ICD patients to identify gender differences in
PA characteristics, goals, barriers, and preferences for PA intervention. The acceptability of mHealth
technology will also be assessed...

## Key facts

- **NIH application ID:** 10559984
- **Project number:** 3K23HL141644-04S1
- **Recipient organization:** UNIV OF NORTH CAROLINA CHAPEL HILL
- **Principal Investigator:** Lindsey Rosman
- **Activity code:** K23 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $54,000
- **Award type:** 3
- **Project period:** 2019-09-05 → 2024-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10559984

## Citation

> US National Institutes of Health, RePORTER application 10559984, Gender Differences in Physical Activity Among Patients with Implantable Cardioverter Defibrillators (ICDs) (3K23HL141644-04S1). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10559984. Licensed CC0.

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