# Microbiota, Probiotic and Dietary Metabolite Control of Enteric Pathogen Virulence

> **NIH NIH R01** · SCRIPPS RESEARCH INSTITUTE, THE · 2023 · $771,519

## Abstract

PROJECT SUMMARY
Key metabolites from microbiota, probiotics and diet can inhibit the virulence properties of enteric pathogens,
but their mechanisms of action are unclear and limit the development of new anti-infectives. To determine the
mechanism(s) of action of prominent microbiota metabolites (short chain fatty acids, aromatic amino acids, bile
acids and others), multi-disciplinary approaches are needed to biochemically identify metabolite-protein targets
in enteric pathogens and characterize their activity on infections in vivo. My laboratory will therefore employ
innovative methods in chemical biology, proteomics and gene editing in bacteria to elucidate how specific
metabolites attenuates enteric pathogen infections. A better understanding of how these metabolites affects the
virulence properties of bacterial pathogens should reveal potential therapeutic targets and facilitate the
development of new anti-infectives to combat bacterial pathogens in animals and humans.

## Key facts

- **NIH application ID:** 10562497
- **Project number:** 1R01AI172915-01
- **Recipient organization:** SCRIPPS RESEARCH INSTITUTE, THE
- **Principal Investigator:** Howard C Hang
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2023
- **Award amount:** $771,519
- **Award type:** 1
- **Project period:** 2022-11-10 → 2027-10-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10562497

## Citation

> US National Institutes of Health, RePORTER application 10562497, Microbiota, Probiotic and Dietary Metabolite Control of Enteric Pathogen Virulence (1R01AI172915-01). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10562497. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*