# Regulation of beige adipocyte plasticity in inguinal white adipose tissue.

> **NIH NIH R01** · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2023 · $572,675

## Abstract

ABSTRACT
Beige adipocyte plasticity refers to the ability to transform between thermogenic active and inactive states in
accordance to environment fluctuations. For example, cold induces the formation of beige adipocytes, while
warm temperature and nutrient excess lead to their disappearance. Previously, we have described the beige
adipocyte renaissance phenomenon that the white adipocytes to be converted to beige adipocytes by cold
indeed have Ucp1 expression history (being Ucp1+-lineage). Interestingly, beige adipocyte renaissance is
regulated by Ucp1--lineage white adipocytes non-cell autonomously.
This proposal will further delineate the cellular and molecular mechanisms of beige adipocyte plasticity. Aim 1
will investigate the in vivo relevance of HDAC4:PRDM16 complex in Ucp1--lineage white adipocytes that is
relevant to beige adipocyte plasticity. Aim 2 will determine the regulatory mechanisms of HDAC4:PRDM16
complex-dependent gene network at molecular and chromatin levels. Aim 3 will exploit the potential contribution
of extracellular matrix remodeling to the maintenance of Ucp1+-lineage beige adipocytes. Prior researches have
suggested a correlation between activities of beige adipocytes and metabolic fitness in both rodents and humans.
Investigations in this direction may provide novel druggable targets to treat obesity and related metabolic
disorders.

## Key facts

- **NIH application ID:** 10563617
- **Project number:** 1R01DK134490-01
- **Recipient organization:** UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- **Principal Investigator:** Biao Wang
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2023
- **Award amount:** $572,675
- **Award type:** 1
- **Project period:** 2023-03-21 → 2027-02-28

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10563617

## Citation

> US National Institutes of Health, RePORTER application 10563617, Regulation of beige adipocyte plasticity in inguinal white adipose tissue. (1R01DK134490-01). Retrieved via AI Analytics 2026-05-27 from https://api.ai-analytics.org/grant/nih/10563617. Licensed CC0.

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