# A scalable system for high-throughput and longitudinal electrophysiology in rodent brain research

> **NIH NIH R44** · SPIKEGADGETS, LLC · 2022 · $168,200

## Abstract

Psychiatric disorders give rise to aberrant patterns of activity within the complex neural circuits
of our brains. Yet, the exact nature of these abnormal patterns is often unknown to developers
of new treatments. The goal of this project is to enable circuit-oriented research of
neuropsychiatric diseases using rodent disease models. The long-term objective is to catalyze
the discovery of new therapeutic targets for a variety of disorders and to provide a tool to study
animal-to-animal variability in neural coding. A new type of research tool will be developed and
commercialized that is specialized for high-throughput, detailed, and long-term neural
measurements in behaving mice. We will develop of a data logging system that is lightweight
enough for a freely-moving mouse to carry as well as flexible electrode technology that is
minimally invasive to brain tissue. By enabling high-throughput and long-term recordings, this
tool provides a practical way to study the progression of circuit dysfunction using large cohorts
of animal disease models.

## Key facts

- **NIH application ID:** 10565321
- **Project number:** 3R44MH118137-04S1
- **Recipient organization:** SPIKEGADGETS, LLC
- **Principal Investigator:** Mattias Peter Karlsson
- **Activity code:** R44 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $168,200
- **Award type:** 3
- **Project period:** 2018-08-01 → 2023-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10565321

## Citation

> US National Institutes of Health, RePORTER application 10565321, A scalable system for high-throughput and longitudinal electrophysiology in rodent brain research (3R44MH118137-04S1). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10565321. Licensed CC0.

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