# Boston OAIC: A Translational Approach to Function Promoting Therapies

> **NIH NIH P30** · BRIGHAM AND WOMEN'S HOSPITAL · 2022 · $29,228

## Abstract

Project Summary
The objective of this Diversity Supplement is to support the research training and career development of Dr.
Rodrigo Valderrábano, an outstanding minority physician scientist. This Diversity Supplement is linked to the
Research Education Core of the Boston Claude D. Pepper Older Americans Independence Center (OAIC), an
NIA-funded P30 grant (P30AG013679; PI: Shalender Bhasin), whose primary aim is to train future independent
research scientists who have the knowledge and skills to translate fundamental mechanisms of disease and
disability during the aging process into novel interventions that can improve the health, physical function, and
well-being of people as they age. The Boston OAIC grant was recently renewed for a period of 5 years which is
sufficient to support the requested 2 years of research proposed in the supplement. The mentored research
project also is thematically linked to OAIC's focus on function promoting therapies, mechanisms of aging and
geroscience targets, and the role of the sirtuin-NAD pathway in aging and innate immune response. The
Diversity Supplement has two closely linked components:
Supplement Aim 1: A 2-year intensive mentored research training under the supervision of Dr. Shalender
Bhasin in the context of an observational study of the role of nicotinamide adenine dinucleotide (NAD) in
modulating the innate immune response and severity of SARS-CoV-2 infection and its relation to the
development of the post-acute sequelae of COVID-19 (PASC), also known as chronic COVID syndrome.
Supplement Aim 2: A structured, individually-tailored, didactic training well integrated with the training program
of the Boston Pepper Center's Research Education Core.
Dr. Valderrábano will work with his mentor in developing an individualized training plan (IDP) as outlined in the
proposal. This plan will be reviewed and approved by the REC Director, Dr. Lewis Lipsitz. The IDP includes the
following categories: 1) Career and Learning Goals, 2) Responsible Conduct of Research Training, 3)
Coursework, 4) Scientific Meetings and Conferences, 5) Professional Development, 6) Papers and Abstracts,
and 7) Grant application/s. Didactic training includes participating in Boston OACI's educational activities for
REC awardees, Advanced Aging Research Seminar Series (AARTSS), structured activities to develop
manuscript and grant writing skills, coursework in ‘OMICS Principles, and Statistical Analysis and
Interpretation. He also will attend the regular research conferences of the OAIC, Men's Health program, and
the Glenn Center for the Biology of Aging. The proposed research training and career development will
facilitate Dr. Valderrábano's advancement towards an independent research career in aging.

## Key facts

- **NIH application ID:** 10569992
- **Project number:** 3P30AG031679-11S1
- **Recipient organization:** BRIGHAM AND WOMEN'S HOSPITAL
- **Principal Investigator:** SHALENDER BHASIN
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $29,228
- **Award type:** 3
- **Project period:** 2008-09-01 → 2026-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10569992

## Citation

> US National Institutes of Health, RePORTER application 10569992, Boston OAIC: A Translational Approach to Function Promoting Therapies (3P30AG031679-11S1). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10569992. Licensed CC0.

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