# The Impact of Opioids on Health Outcomes for Hospitalized Infants

> **NIH NIH R01** · CHILDREN'S HOSPITAL OF LOS ANGELES · 2023 · $622,441

## Abstract

PROJECT SUMMARY
Caring for hospitalized infants requires a comprehensive pain control program aimed at reducing and preventing
pain. While opioids are commonly used when an infant undergoes a painful procedure, opioids can increase the
risk of short- and long-term morbidity. The duration and type of opioids used for hospitalized infants varies widely
between institutions and such wide variations could impact early childhood development and overall healthcare
utilization. In this study, we will create a novel clinical and developmental dataset by merging the Pediatric Health
Information System (PHIS) and the California Perinatal Quality Care Collaborative (CPQCC). This merged
dataset will be the first large retrospective, multi-center cohort representing diverse populations of critically ill,
hospitalized infants linking their in-hospital data with long-term neurodevelopmental outcomes. Using this novel
dataset, we will (1) identify variations in opioid use associated with neurodevelopmental disability and long-term
resource utilization for high-risk infants, (2) quantify cumulative opioid dosing received associated with
neurodevelopmental disability for high-risk infants, and (3) quantify differences in healthcare utilization and costs
associated with high vs. low opioid use among high-risk infants. The expected outcome is a comprehensive
understanding of the variations in opioid use for high-risk infants and its impact on neurodevelopment and
healthcare utilization. Results will lead to interventions for hospitalized infants aimed at minimizing variation in
pain control and will also inform policymakers of a previously unrecognized infant population in need of increased
resources to improve clinical and developmental outcomes.

## Key facts

- **NIH application ID:** 10570951
- **Project number:** 5R01HD105656-02
- **Recipient organization:** CHILDREN'S HOSPITAL OF LOS ANGELES
- **Principal Investigator:** Lorraine I Kelley-Quon
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2023
- **Award amount:** $622,441
- **Award type:** 5
- **Project period:** 2022-03-01 → 2027-02-28

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10570951

## Citation

> US National Institutes of Health, RePORTER application 10570951, The Impact of Opioids on Health Outcomes for Hospitalized Infants (5R01HD105656-02). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10570951. Licensed CC0.

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