# Examine the local glucose dynamics in activity-induced hippocampal neurogenesis

> **NIH NIH R21** · STATE UNIVERSITY NEW YORK STONY BROOK · 2022 · $438,625

## Abstract

Abstract
 The overall goal of this proposal is to explore the local cellular glucose dynamics in regulating activity-
induced hippocampal neurogenesis. Hippocampal neurogenesis sensitively responds to physiological,
behavioral, and unfortunately also pathological stimuli. It has been and is continuously being an essential
question: how brain activities, no matter they are physiological or pathological stimuli, regulate the generation
and circuit integration of new hippocampal neurons in the adult brain. In this explorative proposal, how adult
brain actively regulates the local glucose dynamics in response to brain stimuli and eventually regulates
neurogenesis will be studied. Two sets of experiments have been proposed. 1) Examine the local glucose
dynamics during the hippocampus-engaged behaviors. The glucose dynamics in the astroglia of the dentate
gyrus during the contextual exploration will be determined. The level of glucose in astroglia will be measured
in real time manner during the regular and enhanced exploration behavior. The intercellular transportation
machinery of glucose-derived metabolite, lactate, in the dentate gyrus will be examined. 2) Determine the role
of local glucose dynamics in regulating activity-induced hippocampal neurogenesis. The potential effect of
glucose dynamics in the dentate gyrus on the survival of new hippocampal neurons will be tested. The glucose
transporters of astroglial cells or neural progenitors will be knocked down and the survival of newly generated
neurons will be tested. The findings will ultimately provide insights into the understanding of how the cellular
glucose dynamics change in response to hippocampus-engaged behaviors and how the glucose dynamics
account for the activity-induced hippocampal neurogenesis.

## Key facts

- **NIH application ID:** 10572244
- **Project number:** 1R21NS130290-01
- **Recipient organization:** STATE UNIVERSITY NEW YORK STONY BROOK
- **Principal Investigator:** Shaoyu Ge
- **Activity code:** R21 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $438,625
- **Award type:** 1
- **Project period:** 2022-09-20 → 2024-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10572244

## Citation

> US National Institutes of Health, RePORTER application 10572244, Examine the local glucose dynamics in activity-induced hippocampal neurogenesis (1R21NS130290-01). Retrieved via AI Analytics 2026-05-27 from https://api.ai-analytics.org/grant/nih/10572244. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*