# Animal Core

> **NIH NIH U2C** · YALE UNIVERSITY · 2023 · $37,245

## Abstract

Animal Core- Yale MPMOD
Summary
The overall objective of the Yale Metabolic Phenotyping in Live Models of Obesity and Diabetes (MPMOD)
Animal Core is to provide state-of-the-art husbandry, health care, expedited quarantine, and biosecure housing
and procedure space for assessing and maintaining mice submitted for phenotyping. The MPMOD Animal Core
will continue to reside within the Yale Animal Resources Center (YARC) and will build on the experience gained
from metabolic phenotyping > 10,000 mice as the Animal Core for Yale’s Mouse Metabolic Phenotyping Center
(MMPC). Precise phenotyping depends significantly on the health status of animal subjects. Stable housing and
husbandry minimize the influence of exogenous factors that could impact phenotyping results and reproducibility.
Mice submitted to the MPMOD will share space with cohorts from microbiologically diverse sources. They, as
well as mice housed in resident Yale colonies, must be protected against potential cross-infection by adventitious
agents. MPMOD investigators also must have ready access to the mice soon after they arrive to begin
phenotyping, allowing animals to be studied at younger ages and minimizing costs associated with the
phenotyping process. To address these requirements efficiently and effectively, the Animal Core will provide
facilities and services relevant to: 1) importing mice for metabolic phenotyping using a risk stratified approach;
2) determining the microbiological profile of each imported cohort (within two weeks); 3) providing stable,
biocontainment housing, husbandry and comprehensive health care for mice for the duration required for the
phenotyping exam; 4) reporting and advising MPMOD clients, Core/Sub-Core Directors and MPOD Director on
the health status of submitted mice and to facilitate other potentially applicable services available to advance
phenotyping. The Animal Core will also participate in developing/revising MPMOD consortium guidelines for
animal care.

## Key facts

- **NIH application ID:** 10579073
- **Project number:** 1U2CDK134901-01
- **Recipient organization:** YALE UNIVERSITY
- **Principal Investigator:** JAMES D. MACY
- **Activity code:** U2C (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2023
- **Award amount:** $37,245
- **Award type:** 1
- **Project period:** 2023-02-01 → 2028-01-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10579073

## Citation

> US National Institutes of Health, RePORTER application 10579073, Animal Core (1U2CDK134901-01). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10579073. Licensed CC0.

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