This study is part of the NIH’s Helping to End Addiction Long-term (HEAL) initiative to speed scientific solutions to the national opioid public health crisis. The NIH HEAL Initiative bolsters research across NIH to improve treatment for opioid misuse and addiction. The proposed Mason Coordination and Translation Center (MCTC), led by Dr. Faye S. Taxman of George Mason University (Mason) are leaders in the health-justice disciplines: Mark O’Brien of Addiction Policy Forum (APF); Amy Murphy (Mason); Pam Rodriguez at Center for Health and Justice (CHJ), Treatment Alternatives for Safe Communities; Drs. Danielle S. Rudes and Rebekah Hersch (Mason); Dr. Todd Molfenter at University of Wisconsin-Madison; Dr. Warren Ferguson at University of Massachusetts School of Medicine (UMass); and, Dr. Peter Friedmann at University of Massachusetts-Baystate (UMMS). The collective team are leaders in both research and practice arenas to facilitate new policies, practices, and interventions at the individual and organizational level. This makes the MCTC team uniquely qualified to achieve the collaborative, transdisciplinary approach necessary for the success of JCOIN. Individually and collectively the team has a strong belief in, and track record for, improving the quality of care for justice-involved individuals and growing the number of scholars researching this critical justice-health arena to improve individual- and system- level outcomes, increasing the number of justice and/or health organizations engaging in research studies, and advancing the care provided to people with opioid use disorder and their families. And, our team has extensive and dynamic experience working with populations affected by both mass incarceration and substance abuse policies. The alignment of our values with JCOIN goals, along with our discipline and geographic diversity, makes this team uniquely situated to serve JCOIN and NIDA. MCTC goals will include: 1) coordination among partners and infrastructure for day-to-day activities; 2) facilitation of multidirectional JCOIN communication; 3) wide dissemination of research findings; 4) development and maintenance of an education infrastructure to grow experienced justice researchers; and 5) build coalitions to better serve research-to-practice, practice-to-research goals. Five Cores will support MCTC: 1) Administrative (Admin) Core, facilitating communication across internal and external JCOIN stakeholders; 2) Rapid Response and Pilot Research (RRPR) Core, providing funding for pilot or small innovative studies; 3) Dissemination and Stakeholder Engagement (D/SE) Core, creating a participatory research partnership and providing NIDA with easy access to stakeholder groups; 4) Research Education (Learning Experiences to Advance Practice [LEAP]) Core, educating and mentoring researchers and practitioners to expand knowledge and skills; and 5) Implementation and Translational Research (I/Trans) Core, executing rigorous studies to test Dissemi...