The ND INBRE and the University of North Dakota School of Medicine and Health Sciences is proposing the purchase of a Leica Bond RX to automate immunostaining for research and training in clinical and translational research. The UND SMHS is providing $40,000 towards the purchase price, newly completed shell space in the medical student research laboratory, and a staff Ph.D. to train investigators, assist in operation of the instrument, and support the use by all stakeholders. Boarded pathology faculty in Department of Pathology will participate in the interpretation of results. The Leica Bond RX will support the research of multiple CoBRE awards, the DaCCoTA CTR, and multiple investigator-initiated research projects. The ND INBRE research cores are designed to provide state-of-the-art technology that cannot be sent to commercial vendors and must be performed “in house”. These current cores include: microscopy (confocal, fluorescence, laser capture microdissection, and stereology); flow cytometry (including cell sorting); and, animal behavior (including optogenetic capacity). Biotechnology and Drug companies do use commercial vendors for immunostaining, but costs for these commercial services exceeds the budgets of most academic research. This technology, unless provided by ND INBRE, is also unavailable to the PUIs and TCUs which the program is dedicated to serve. Strong cores equipped with modern technology are crucial for North Dakota which has a low population and large land mass. The ability to engage undergraduates at rural primarily undergraduate institutions and tribal colleges in the use of cutting-edge technology is a mission of the ND INBRE infrastructure program.