# The Indiana University-Ohio State University Maternal and Pediatric Precision in Therapeutics Data, Model, Knowledge, and Research Coordination Center (IU-OSU MPRINT DMKRCC)

> **NIH NIH P30** · INDIANA UNIVERSITY INDIANAPOLIS · 2022 · $974,760

## Abstract

Project Summary/Abstract
Early-onset, or preterm, preeclampsia occurs in only 0.5% of pregnancies, but it is associated with a high risk of long-
term maternal complications, as well as high fetal morbidity and mortality. Biomarkers associated with early-onset
preeclampsia are needed to identify women at risk of developing early-onset preeclampsia, guide treatment options,
and support development of new therapeutic approaches to prevent and treat the disease. Additionally, it is important
to understand the long-term consequences of preterm preeclampsia in both the mother and child. However, due to the
low incidence of early-onset preeclampsia, it is difficult to obtain data and necessary biospecimens from a sufficient
number of women through a single center or study. Whether collected as a prospective biobanking endeavor or leftover
residual samples from clinical studies, numerous biospecimens from maternal and pediatric patients reside within
storage facilities across the world. These untapped biosamples and their associated data have the potential to greatly
enhance maternal and pediatric therapeutics research, especially for rare conditions and diseases such as early-onset
preeclampsia. However, there is no single resource to identify sources of maternal and pediatric biospecimens, so often
translational researchers seeking such samples may not be aware of their existence. This proposal will characterize the
landscape of available maternal and pediatric biospecimens and survey investigators to understand the needs of the
translational research community. We will develop The Collaborative Online Perinatal & PEdiatric Repository (COPPER),
a user-friendly platform to facilitate identification of biobanks and networks with residual biospecimens available to
support maternal and pediatric precision therapy research. Through surveys and working group discussions, we will seek
to understand the evolution of regulations relating to future use of biospecimens and propose strategies to enhance the
ability to link long-term pediatric outcomes to samples collected during the perinatal period. At the end of this project,
we will develop a centralized resource providing information on biorepositories which could support maternal and
pediatric translational research and precision therapeutics, develop proposals to enhance the ability to link maternal
and child data and specimens, and identify biospecimens and associated clinical data to support future work to develop
biomarkers and therapeutic approaches to prevent and treat early-onset preeclampsia.

## Key facts

- **NIH application ID:** 10584124
- **Project number:** 3P30HD106451-01S1
- **Recipient organization:** INDIANA UNIVERSITY INDIANAPOLIS
- **Principal Investigator:** Lang Li
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $974,760
- **Award type:** 3
- **Project period:** 2022-05-01 → 2023-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10584124

## Citation

> US National Institutes of Health, RePORTER application 10584124, The Indiana University-Ohio State University Maternal and Pediatric Precision in Therapeutics Data, Model, Knowledge, and Research Coordination Center (IU-OSU MPRINT DMKRCC) (3P30HD106451-01S1). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10584124. Licensed CC0.

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