# Molecular Analysis of Developmental Brain Disorders Associated with Synaptic Pathology

> **NIH NIH R01** · DUKE UNIVERSITY · 2022 · $752,628

## Abstract

ABSTRACT
The molecular mechanisms of synaptopathy that arise downstream of the large number of gene conferring risk
for these disorders remains unclear. Particularly, how different risk genes may segregate into common
molecular mechanisms has been challenging to identify. Likewise, how genetic missense variants result in
pathology remains an enigma. These gaps in knowledge pose a significant barrier to the field and limit our
ability to envision stratagies to ameliorate pathogenesis. In this project, we will develop and utilize innovative
proteomic, scRNA-seq, and genome engineering approaches to solve these problems at larger scales than
previously possible in animals. We anticipate these data will provide a new and unparalleled molecular
framework for ASD and related disorders as well as future studies on new targets to beneficially modulate
behavior.

## Key facts

- **NIH application ID:** 10585092
- **Project number:** 2R01MH111684-06
- **Recipient organization:** DUKE UNIVERSITY
- **Principal Investigator:** SCOTT H SODERLING
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $752,628
- **Award type:** 2
- **Project period:** 2017-06-16 → 2027-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10585092

## Citation

> US National Institutes of Health, RePORTER application 10585092, Molecular Analysis of Developmental Brain Disorders Associated with Synaptic Pathology (2R01MH111684-06). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10585092. Licensed CC0.

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