# Using Common Fund datasets for prioritization of disease-associated genetic variants

> **NIH NIH R03** · LA JOLLA INSTITUTE FOR IMMUNOLOGY · 2022 · $366,000

## Abstract

Abstract
Genome-wide association studies (GWAS) have highlighted that disease-associated human genetic variants are
prevalent in noncoding regions and for most of them the biological function or gene target remain
uncharacterized. To better annotate such disease variants, NIH-funded consortia created comprehensive maps
of putative regulatory elements and identified SNPs associated with gene expression (eQTLs) for different
tissues and primary cell types. In parallel, breakthroughs in capturing the 3D genome structure have
demonstrated the importance of cell-type-specific physical proximity between genes and their regulatory
elements. This 3D view provided a new way through which disease-associations of certain variants can be
explained. There is an increasing interest in utilization of chromatin loops for GWAS variant annotation, however,
to the best of our knowledge, there is no comprehensive study incorporating eQTL data and high-resolution
chromatin looping information across many different matched/related cell types and tissues to interpret GWAS
variants identified for a large set of diseases. To goal of this proposal is to utilize NIH Common Fund datasets
(GTEx and 4D Nucleome) as well as other published chromatin loop and eQTL data to carry out different
integrative approaches for better annotation of disease-associated genetic variants. This will lead to the
development of a framework and best practices for integrative analysis of loops, eQTLs and GWAS signals. The
developed framework will be tested on a large number of diseases and disease-relevant cell types to create a
substantial online resource for researchers. For a subset of the studied diseases, for which we have ongoing
research interests, we will further analyze the identified novel genes, genetic variants and overlapping regulatory
elements to determine potential targets that warrant further investigation.

## Key facts

- **NIH application ID:** 10585864
- **Project number:** 1R03OD034494-01
- **Recipient organization:** LA JOLLA INSTITUTE FOR IMMUNOLOGY
- **Principal Investigator:** Ferhat Ay
- **Activity code:** R03 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $366,000
- **Award type:** 1
- **Project period:** 2022-09-20 → 2024-09-19

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10585864

## Citation

> US National Institutes of Health, RePORTER application 10585864, Using Common Fund datasets for prioritization of disease-associated genetic variants (1R03OD034494-01). Retrieved via AI Analytics 2026-08-12 from https://api.ai-analytics.org/grant/nih/10585864. Licensed CC0.

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