# Neuroinflammation, Neuronal IL-1R1, and Behavior

> **NIH NIH R01** · FLORIDA ATLANTIC UNIVERSITY · 2023 · $342,167

## Abstract

Project Summary
Neuroinflammation is a significant contributor to most CNS disorders including neurodegenerative
diseases and psychological disorders. A hallmark of neuroinflammation is the increased expression of the
proinflammatory cytokine interleukin-1 (IL-1) in the brain. How IL-1 causes neuro- and psycho-
pathologies is poorly understood. We have recently discovered that the receptor for IL-1, IL-1R1, is
expressed in specific sets of neurons in the brain. These neuronal IL-1R1s, nIL-1R1, modulate neuronal
activity via non-canonical signaling pathways to alter neuronal function and circuit connectivity. This
application is designed to: 1) map nIL-1R1 distribution in the brain, 2)demonstrate the involvement of
nIL-1R1 in neuroinflammation induced behavioral deficits and neuropathology, and 3) elucidate the
mechanisms of nIL-1R1 mediated neuromodulation.

## Key facts

- **NIH application ID:** 10586078
- **Project number:** 5R01NS116914-04
- **Recipient organization:** FLORIDA ATLANTIC UNIVERSITY
- **Principal Investigator:** Ning Quan
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2023
- **Award amount:** $342,167
- **Award type:** 5
- **Project period:** 2020-04-01 → 2025-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10586078

## Citation

> US National Institutes of Health, RePORTER application 10586078, Neuroinflammation, Neuronal IL-1R1, and Behavior (5R01NS116914-04). Retrieved via AI Analytics 2026-05-27 from https://api.ai-analytics.org/grant/nih/10586078. Licensed CC0.

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