# Brain Injury and Dysmaturation in Newborns with Congenital Heart Disease Born Preterm

> **NIH NIH R01** · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2023 · $894,975

## Abstract

Brain Injury and Dysmaturation in Newborns with Congenital Heart Disease Born Preterm.
Abstract:
Preterm birth and congenital heart disease (CHD) are two of the most common sources of perinatal morbidity
in high resource countries. Both conditions are associated with acquired brain injury and adverse
neurodevelopmental outcomes. Very little is known about the combined risk for newborns with congenital
heart disease that are born preterm and how this risk is affected by variable approaches to palliative or
definitive surgical strategies to repair heart defects. In addition to brain injury, an increasing number of genetic
anomalies have been identified in CHD that may contribute to ND outcomes. Our extensive experience
imaging term babies with CHD and preterm babies without CHD, combined with high and increasing volume of
this vulnerable population at our two centers uniquely positions us to describe the risk and magnitude of
acquired brain injury as well as comparative brain development in CHD newborns born preterm with respect to
intervention strategies. Our long-term goal is to optimize neurodevelopmental outcomes. In this proposal, we
will leverage cross-center practice variability in timing and choice of surgical interventions, palliative versus
definitive, to determine the association of surgical intervention strategy with brain development and risk of brain
injury. We will also perform a comprehensive genetic evaluation to determine how genetic anomalies alter
susceptibility to brain injury and ND outcome.

## Key facts

- **NIH application ID:** 10586934
- **Project number:** 1R01HL165400-01A1
- **Recipient organization:** UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- **Principal Investigator:** Patrick Sean McQuillen
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2023
- **Award amount:** $894,975
- **Award type:** 1
- **Project period:** 2023-03-01 → 2028-02-28

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10586934

## Citation

> US National Institutes of Health, RePORTER application 10586934, Brain Injury and Dysmaturation in Newborns with Congenital Heart Disease Born Preterm (1R01HL165400-01A1). Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/grant/nih/10586934. Licensed CC0.

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