# Glomerular and Tubular Function in the Recovering Kidney

> **NIH NIH R01** · VETERANS MEDICAL RESEARCH FDN/SAN DIEGO · 2023 · $437,567

## Abstract

Project Summary Abstract
This research will provide information on the inner working of the kidney as it recovers from acute injury.
Recovery of the kidney from acute injury is often incomplete and leaves behind a kidney that is prone to
subsequent permanent decline due to physical and metabolic stresses of trying to compensate for incomplete
healing. Ideally, targeted intervention would hasten recovery from acute kidney injury and diminish its long-
term consequences. However, major knowledge gaps in the area of renal recovery currently preclude a rational
approach to treatment. Knowledge gaps include the physical reason why the injured kidney appears to filter less
fluid, the vulnerability of the injured kidney to be further injured by changes in blood pressure, or whether
standard medical treatments or prescribed diets are helpful or harmful in patients recovering from kidney injury.
Kidney features that are observed at the whole-kidney level emerge from events at the microscopic level and
treatments have their direct effect at the microscopic level. However, there can be multiple combinations of
microscopic events that could account for a given observation at the whole-kidney level. Therefore, microscopic
behavior cannot be deduced from whole-kidney behavior and must be observed directly. This cannot be done in
humans but can be done in rat models of human kidney injury using specialized techniques uniquely available
to the investigators. Through these methods, this research will determine the effects of simple maneuvers on
multiple internal variables thereby establishing boundary conditions for efficient design of future clinical trials
in the field of kidney recovery.

## Key facts

- **NIH application ID:** 10587898
- **Project number:** 1R01DK132690-01A1
- **Recipient organization:** VETERANS MEDICAL RESEARCH FDN/SAN DIEGO
- **Principal Investigator:** SCOTT Culver THOMSON
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2023
- **Award amount:** $437,567
- **Award type:** 1
- **Project period:** 2023-01-01 → 2027-11-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10587898

## Citation

> US National Institutes of Health, RePORTER application 10587898, Glomerular and Tubular Function in the Recovering Kidney (1R01DK132690-01A1). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10587898. Licensed CC0.

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