# Physiology and Behavior Core

> **NIH NIH U2C** · UNIVERSITY OF CALIFORNIA AT DAVIS · 2023 · $238,198

## Abstract

ABSTRACT—PHYSIOLOGY AND BEHAVIOR (PB) CORE
Numerous physiological and behavioral causes, complications and consequences of diabetes and obesity can
be assessed in mouse models. Key physiological and behavioral phenotypes in mice are providing useful
outcome measures and translational markers to inform the development of new treatments for these and other
metabolic conditions in humans. The mission of the Physiology and Behavior (PB) Core will be to advance the
understanding of behavioral manifestations and pathophysiological mechanisms and systemic consequences
of disease. A selection of unique, complex, and innovative in vivo tests and procedures will be combined with
consultative services on planning, analyzing, and interpretation of experimental results and outcomes
measures in living mice. PB Core services will complement those of other Cores in the national MPMOD
Consortium and the MMH and Animal Cores of the Center. The PB Core will also leverage the expertise and
capabilities of several laboratories, cores, and service centers at UC Davis to provide ancillary analytical
services and resources in support of investigators using the Center for studies on live mice. The PB Core will
be service-oriented, client-facing, and research-supportive. The PB Core will be staffed by a Leader, co-
Leader, Core Coordinators, Technical Specialists, and 5 Scientific Consultants.
The mission of the PB Core will be accomplished through the following 2 Specific Aims:
Specific Aim 1: Provide innovative, comprehensive, high quality, state-of-the art physiological and
behavioral testing in vivo of obesity and diabetes phenotypes to investigators from across the
biomedical community.
Specific Aim 2: Provide clients with consultation services and advice on study design, test selection,
and experimental planning, analysis and interpretation of results and outcomes measures, in the areas
of physiology and behavior related to diabetes, obesity, and other metabolic disorders.
Under these specific aims, the PB Core will carry out the following activities:
 • Providing comprehensive phenotyping tools for in vivo characterization of ocular, cardiovascular,
 kidney, and gastrointestinal functions in mouse models of obesity and diabetes in both sexes of mice;
 • Offering a battery of tests probing multiple behavioral domains (general health, motor capabilities,
 anxiety, affective and social behaviors, and memory and learning) in mice to understand how obesity
 and metabolic disorders influence neurophysiological and executive functions;
 • Conducting analyses of exercise, gait, sleeping stages, spindle events, and apneas during sleep by
 respiratory physiology paired with neurophysiology, which will provide essential information for
 studying alterations of energy balance in mice and complement services provided by the MMH Core;
 • Providing unique, innovative services to assess special physiological functions impacted by diabetes
 and/or obesity, including intestinal barr...

## Key facts

- **NIH application ID:** 10588975
- **Project number:** 1U2CDK135074-01
- **Recipient organization:** UNIVERSITY OF CALIFORNIA AT DAVIS
- **Principal Investigator:** Jill Lynn Silverman
- **Activity code:** U2C (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2023
- **Award amount:** $238,198
- **Award type:** 1
- **Project period:** 2023-02-01 → 2028-01-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10588975

## Citation

> US National Institutes of Health, RePORTER application 10588975, Physiology and Behavior Core (1U2CDK135074-01). Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/grant/nih/10588975. Licensed CC0.

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