# Molecular Mechanisms Underlying Adaptor-Mediated Integrin Signaling in a Species-Specific Manner

> **NIH NIH R35** · RESEARCH INST OF FOX CHASE CAN CTR · 2022 · $69,354

## Abstract

Project Summary
This is a request for an NIGMS Administrative Supplement to NIGMS grant R35GM119560, to purchase a J-
1100 Circular Dichroism (CD) Spectropolarimeter. Our previous structural and functional studies allow us to
design peptidomimetic inhibitors targeting integrin-related diseases such as thrombotic disorders, cardiovascular
diseases, and many autoimmune diseases. Our data suggest the helicity of the peptidomimetics is required for
its inhibitory function. Access to the J-1100 CD Spectropolarimeter will provide the necessary capabilities to
maximize productivity and fully achieve the aims of the proposed research project. Institutional matching funds
will contribute to the purchase of this instrument.

## Key facts

- **NIH application ID:** 10591322
- **Project number:** 3R35GM119560-06S1
- **Recipient organization:** RESEARCH INST OF FOX CHASE CAN CTR
- **Principal Investigator:** Jinhua Wu
- **Activity code:** R35 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $69,354
- **Award type:** 3
- **Project period:** 2016-09-01 → 2026-12-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10591322

## Citation

> US National Institutes of Health, RePORTER application 10591322, Molecular Mechanisms Underlying Adaptor-Mediated Integrin Signaling in a Species-Specific Manner (3R35GM119560-06S1). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10591322. Licensed CC0.

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