Vanderbilt University Medical Center is responding to RFA-TR-22-012 to be the Recruitment Resource Center (RRC). We will work collaboratively with each ERN study team and the other HEAL ERN Resource Centers and continue to develop and monitor comprehensive strategies to address barriers to recruitment and retention in the five funded HEAL pain studies and two additional studies, demonstrate their effectiveness in recruiting diverse participants and broadly disseminate evidence on the most effective approaches to recruitment and retention of people who have pain. Our Recruitment Resource Center application has the following Specific Aims: Specific Aim 1. Develop comprehensive recruitment and retention strategies for HEAL Pain ERN clinical trials to ensure studies efficiently enroll and retain a sufficient number of participants who represent the diversity of the study population Specific Aim 2. Provide centralized participant-centered recruitment and retention services to support HEAL Pain ERN sites in identifying, approaching, screening, consenting, enrolling, and retaining participants. Specific Aim 3. Implement, study, and refine novel recruitment and retention strategies (such as EHR-based participant screening, e-consent, embedding patients on study teams, and behavioral, informational and/or social incentives) and disseminate evidence on the most effective approaches to recruitment and retention of people who have pain. Our collaboration with ERN investigators and integration with the other TIN Resource Centers will maximize the likelihood of successful and timely completion of the HEAL Effectiveness Research Network clinical trials, leading to translation of research findings to the effective interventions and management strategies for pain while, improving functional outcomes, and reducing pain across the continuum of acute to chronic pain.