ABSTRACT The virus responsible for causing the COVID-19 pandemic, SARS-CoV-2, has a diverse genomic landscape that is quickly evolving. It has been challenging for the medical and scientific community to keep up with numerous variants and their association with clinical outcomes. The impact of the pandemic in the United States has been devasting for the healthcare industry and economic infrastructure. Enhanced genomic surveillance efforts are needed to be better understand how transmission patterns and virus evolution affects clinical outcomes. This project proposal focuses on increasing SARS-CoV-2 genome sequencing in pediatric patients and disseminating the demographic analysis for all samples sequenced in the State of Delaware Public Health Laboratory (>10,000). This project is leveraging key expertise in a collaborative effort between the top pediatric hospital in Delaware, Nemours, and the State of Delaware Public Health Laboratory.