# Cancer Animal Models

> **NIH NIH P30** · EMORY UNIVERSITY · 2022 · $102,723

## Abstract

CANCER ANIMAL MODELS SHARED RESOURCE
PROJECT SUMMARY/ ABSTRACT
The Cancer Animal Models Shared Resource (Mouse SR; Categories 1.02, 1.04, 1.06) of Winship Cancer
Institute of Emory University (Winship) was established in 2012 to promote cancer discovery by providing
expertise to Winship investigators in the development and analysis of animal models of cancer, with a particular
focus on genetically engineered mouse models (GEMMs). Since its inception, Mouse SR has supported
investigators across all four Winship programs (Cancer Genetics and Epigenetics (CGE), Cancer Cell Biology
(CCB), Discovery and Developmental Therapeutics (DDT), and Cancer Prevention and Control (CPC)) with
genetic mouse models of colon, prostate, breast, pancreatic, and lung cancer and brain tumors. The number of
Winship members actively using Mouse SR increased during the current funding period from seven to twenty-
one individual investigators. In 2014, Winship appointed a new Mouse SR Director and added an additional full-
time staff member. Mouse SR has expanded its services to include cell-line and patient-derived orthotopic
xenograft models and has acquired an IVIS Spectrum pre-clinical optical imaging system. The IVIS Spectrum is
capable of detecting high-resolution bioluminescent and fluorescent sources deep within the animal and allows
for longitudinal monitoring of therapeutic responses in vivo. Mouse SR provides a significant cost savings to
Winship investigators by offering a source of centralized expertise and equipment. Future goals of Mouse SR
include establishing immune-competent syngeneic models to support testing of immunotherapies and to
establish a bank of GEMM-derived cells lines for rapid in vitro compound screening prior to in vivo studies. During
the current funding period, Mouse SR has supported multiple grant applications and awards, contributed to high-
impact publications, and supported the successful submission for two new multi-PI R01s and a U01 award. To
further support Winship's programmatic initiatives, Mouse SR proposes to: 1) support outstanding cancer
research by providing access to high quality services and technologies that promote scientific collaboration and
translational potential and 2) provide the outstanding in vivo imaging technologies and associated expertise in
support of pre-clinical animal model research.

## Key facts

- **NIH application ID:** 10595759
- **Project number:** 3P30CA138292-13S3
- **Recipient organization:** EMORY UNIVERSITY
- **Principal Investigator:** Melissa GILBERT-ROSS
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $102,723
- **Award type:** 3
- **Project period:** 2009-04-07 → 2023-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10595759

## Citation

> US National Institutes of Health, RePORTER application 10595759, Cancer Animal Models (3P30CA138292-13S3). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10595759. Licensed CC0.

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