# Bioinformatics Support for Toxicogenomics Technologies

> **NIH NIH N01** · SCIOME, LLC · 2022 · $200,000

## Abstract

Projects needing support for toxicogenomic analysis included 1) support for circulating cell free DNA (ccfDNA); 2) support for Mouse Aging study by providing dendogram and SNP analysis for 10 strains of mice; 3) support epigenomic analysis of DNA methylation of arsenic-related changes in an in vitro model of cellular transformation; 4) analysis of 3D spheroids of HepaRG.  Differential gene expression from TempO-Seq data was performed with fold chagnes and pvalues; 5) support was provided for analysis of microarray toxicogenomic data for placenta and liver from animals exposed to PFAS compounds; 6) support was provided for analysis of AFFF (aqueous film-forming foams) fpr comparative analysis of toxicity after in vitro exposures in HTT assays.

## Key facts

- **NIH application ID:** 10596964
- **Project number:** 273201700001C-P00009-9999-3
- **Recipient organization:** SCIOME, LLC
- **Principal Investigator:** RUCHIR SHAH
- **Activity code:** N01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $200,000
- **Award type:** —
- **Project period:** 2017-03-24 → 2022-09-23

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10596964

## Citation

> US National Institutes of Health, RePORTER application 10596964, Bioinformatics Support for Toxicogenomics Technologies (273201700001C-P00009-9999-3). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10596964. Licensed CC0.

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