We propose to expand the scope of the current NIMHD-funded U54 (Transdisciplinary Research, Equity & Engagement Center [TREE Center]), maximizing our participatory and transdisciplinary team science aimed at testing multi-level interventions that advance behavioral health and health equity for diverse racial, ethnic, rural, urban, border and tribal populations in the southwest. Drawing on the expertise of transdisciplinary health researchers, a well- established statewide Communities of Practice Network embedded within a strong co- leadership structure, this supplement will enhance the participatory transdisciplinary team science of multi-level intervention research, employ culturally adapted approaches, and accelerate the knowledge translation and dissemination of our Year 1-5 results into practice, research, and policy. By 2050, 50% of the US population is expected to be racial/ethnic minority, underscoring the significance of disparities in behavioral-related health outcomes in these populations. New Mexico is a minority-majority state where 49% of the population identify as Latino and 11% as American Indian/Alaska Native (AI/AN); 34% of the state’s 2.1 million residents live in rural and frontier areas. Given our unique racial, ethnic and geographic diversity, we are uniquely situated to further our public health impact by advancing transdisciplinary, culturally-centered, and community-engaged approaches in order to reduce the devastation from behavioral health inequities in New Mexico and nationally. The grave impacts of structural racism, pre-existing health inequities, and the COVID-19 pandemic on behavioral health is a pressing public health priority that our TREE Center will address in this proposed supplement. We will enhance the participatory transdisciplinary team science of multi-level intervention research, employ culturally-adapted approaches, and accelerate the knowledge translation and dissemination of our Year 1-5 results into practice, research and policy through three aims: 1) Integrate the team science generated in Years 1-5 of the Center across cross-cutting etiological, methodological, and intervention innovations for translation into the next stages of research, implementation, and dissemination; 2) Train and mentor early- stage under-represented minority pilot research project investigators to conduct rigorous, community-engaged, multi-level, intervention research focused on behavioral health disparities in New Mexico; and 3) Build on the established Communities of Practice for Dissemination and place-based networks in order to accelerate knowledge translation and co-dissemination of transdisciplinary research evidence into practice, policy and future research.