# Threat-Related Negative Valence Systems, Child Victimization, and Anxiety_Supplement

> **NIH NIH R01** · MEDICAL UNIVERSITY OF SOUTH CAROLINA · 2022 · $221,112

## Abstract

Interpersonal violence (IPV) exposure affects 1 in 2 youth and levies tremendous physical and mental health
burdens on victims and society. Childhood IPV exposure is a well-established risk factor for anxiety and other
mental health problems across the lifespan. A paucity of longitudinal studies assessing multiple threat-related
mechanisms, across multiple units of analysis, and at key times in development has been a critical barrier to
informing the design of personalized treatments to target root causes of post-IPV psychopathology. The
overarching goal of this project (the “CHARM study”) is to examine developmental trajectories of threat-related
NVS measures into adolescence, as a function of exposure to IPV, in an effort to better link IPV and anxiety
through changes in these measures. The specific aims of this project are: 1) to identify threat-related NVS
constructs that connect lifetime IPV to anxious symptoms in youth cross-sectionally; 2) to investigate
longitudinally the degree to which IPV sensitizes trajectories of NVS measures across three age cohorts (grades
3, 6, 9 at baseline); and 3) to investigate the degree to which trajectories of NVS measures predict anxiety
symptoms over time after accounting for initial anxiety symptoms and IPV status. The study had successfully
recruited its full sample (N=364) and longitudinal retention was progressing as planned until March, 2020, when
the COVID-19 pandemic (and subsequent mandatory guidelines impacting in-person data collection) reduced
retention across the representative sample. Pandemic disruptions have required increased intensive efforts in
participant retention, particularly for the final assessment (Lab Visit 3) that includes the follow-up fMRI scan,
which has translated into a delayed timeline and increased costs. The proposed Administrative Supplement is
essential to help cover these unexpected costs to complete the outstanding in-person data collection, as well as
final data cleaning, analysis, and write up of results, ensuring that the longitudinal aims are successfully met and
that maximum impact is yielded from the study.

## Key facts

- **NIH application ID:** 10597417
- **Project number:** 3R01MH112209-05S1
- **Recipient organization:** MEDICAL UNIVERSITY OF SOUTH CAROLINA
- **Principal Investigator:** CARLA KMETT DANIELSON
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $221,112
- **Award type:** 3
- **Project period:** 2022-04-01 → 2024-01-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10597417

## Citation

> US National Institutes of Health, RePORTER application 10597417, Threat-Related Negative Valence Systems, Child Victimization, and Anxiety_Supplement (3R01MH112209-05S1). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10597417. Licensed CC0.

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