# Improving Neurological Health in Aging via Neuroplasticity-based Computerized Exercise (INHANCE)

> **NIH NIH R44** · POSIT SCIENCE CORPORATION · 2022 · $201,074

## Abstract

PROJECT ABSTRACT
Advancing age is often accompanied by a decline of key neuromodulatory centers of the brain that support adaptive
neuroplasticity. Deterioration of the underlying neurophysiology of the brain predisposes the individual to pathological and
age-related cognitive decline. We propose to deploy a computerized cognitive training program (INHANCE) developed via
two successful SBIR-funded phase II programs (R44AG039965; R44NS071780). The program will combine two previously
validated, but historically independent, exercises that based on prior research may interact to reduce the long-term risk of
dementia onset. We shall conduct a double-blind, parallel-arm, placebo-controlled, randomized clinical trial that will assess
the short- and long-term efficacy of the program to improve neuromodulatory status (via positron-emission tomography)
and neuropsychological outcomes (via standard assessment measures). The broader objectives of the project are two-fold.
One is to address the rapid rise in neurodegenerative disease and the other is to shed light on the underlying neuromodulatory
mechanism(s) through which certain forms of cognitive training achieve neuropsychological improvement. An effective,
low-cost, and highly-scalable program available on the most popular internet-connected devices offers global reach and the
possibility of extending the cognitive health of older adults. With effective computerized tools in hand we can enrich the
lives of patients and their families, alleviate the enormous financial cost associated with minor and major forms of
impairment, and progress swiftly toward the goal of creating a healthier society and a more efficient healthcare system.

## Key facts

- **NIH application ID:** 10597850
- **Project number:** 3R44AG039965-06S1
- **Recipient organization:** POSIT SCIENCE CORPORATION
- **Principal Investigator:** Mouna Attarha
- **Activity code:** R44 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $201,074
- **Award type:** 3
- **Project period:** 2011-09-01 → 2024-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10597850

## Citation

> US National Institutes of Health, RePORTER application 10597850, Improving Neurological Health in Aging via Neuroplasticity-based Computerized Exercise (INHANCE) (3R44AG039965-06S1). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10597850. Licensed CC0.

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