# Improving the translational value of head and neck cancer patient-in-mouse models

> **NIH NIH R37** · UNIVERSITY OF WISCONSIN-MADISON · 2022 · $65,621

## Abstract

Project Summary
Patient-derived model systems are commonly used to study tumor biology and test novel treatments for head
and neck cancer. Our goal is to improve the use of mammalian model systems of head and neck cancer to
improve treatment outcomes for patients using valid, predictive, well characterized models. The goal of this
supplement is to study cancer evolution and therapeutic response with rigorous assessment of tumor biology
and genomic alterations to understand how choices made at the time of establishing models impact their
relevance over time. Aim 1 will assess the role of heterotopic vs. orthotopic implantation on the therapeutic
response and biology of the tumor. Aim 2 will test the concordance of response between patient-derived
models and patients. We will use this supplement to support a minority graduate student in the medical physics
program to study the effect of radiation on tumor evolution, to provide her with additional training in team
science, mentoring, teaching, and communication to support her pursuit of an independent research career.

## Key facts

- **NIH application ID:** 10598311
- **Project number:** 3R37CA255330-02S1
- **Recipient organization:** UNIVERSITY OF WISCONSIN-MADISON
- **Principal Investigator:** Randall J. Kimple
- **Activity code:** R37 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $65,621
- **Award type:** 3
- **Project period:** 2021-07-01 → 2026-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10598311

## Citation

> US National Institutes of Health, RePORTER application 10598311, Improving the translational value of head and neck cancer patient-in-mouse models (3R37CA255330-02S1). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10598311. Licensed CC0.

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