# Genomics Shared Resource

> **NIH NIH P30** · UNIVERSITY OF COLORADO DENVER · 2023 · $1

## Abstract

ABSTRACT 
Overview: Genetics and genomics technologies are essential tools for cancer research and help to improve 
care for cancer patients. The Genomics Shared Resource (GSR) provides University of Colorado Cancer Center 
(UCCC) members high-quality and cost-effective services and technical support for high-throughput genomic 
investigation to study cancer pathogenesis, therapeutics, genetic susceptibility, and biomarker development, and 
develop strategies for targeted and personalized medicine. Services and Expertise: GSR offers methodologies 
for quantitative assessment of DNA/RNA including evaluation of human and murine cells harboring shRNA and 
CRISPR libraries that UCCC members obtain from the Functional Genomics Shared Resource (FGSR). GSR 
provides genome-wide analyses of DNA sequence, transcriptomes, epigenetics and cytogenomics using next 
generation sequencing (NGS) and gene microarrays; and single cell genomic and transcriptomic analyses 
including single cell immune profiling and spatial gene expression. Equipment: GSR houses equipment to 
support DNA next-generation sequencing (NGS) (Illumina NovaSeq 6000 and Illumina MiSeq); single-cell 
genomics (10X Genomics Chromium; Mission Bio Tapestri; Fluidigm C1 and Biomark HD Systems); DNA 
microarray analysis (Affymetrix GeneChip systems; Illumina iScan system; and Agilent SureScan Microarray 
system) and Affymetrix, Agilent and Illumina microarray and sequencing software. Management: GSR is an 
institutional core managed by the UCCC, and is overseen by H Ford, Associate Director for Basic Research. 
Use of Services: Since July 2016, GSR has provided services to 432 investigators. Twenty-nine percent of 
users (125) were UCCC members, representing all four programs and resulting in 118 peer reviewed 
publications, 18% with an IF ≥ 10. Operating Budget: CCSG funding represents 2% of the annual operating 
budget of $4.4M. The remaining support is from user fees (98% $4.3M). Innovation and Developments: The 
GSR team supports UCCC members with commercial genomic tools including single cell genomics for cancer 
research. GSR develops and optimizes customized methods for specific cancer research applications. 
Consultation and Education: GSR provides consultation for designing and analyzing reliable genomics 
experiments in conjunction with the Biostatistics and Bioinformatics SR (BBSR) and helps members stay updated 
with the advancement of technology through seminars and hands-on training. Future Directions: GSR has four 
main future directions that are in high demand by UCCC investigators: 1) optimize 10X Genomics Visium spatial 
gene expression solution and methods for single cell genomics; 2) adopt Olink proteomics with NGS readouts; 
3) adopt Nanopore single molecule sequencing; and 4) enhance NGS capability by continuously upgrading our 
technologies.

## Key facts

- **NIH application ID:** 10599162
- **Project number:** 5P30CA046934-35
- **Recipient organization:** UNIVERSITY OF COLORADO DENVER
- **Principal Investigator:** RICHARD D SCHULICK
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2023
- **Award amount:** $1
- **Award type:** 5
- **Project period:** 1997-04-04 → 2027-01-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10599162

## Citation

> US National Institutes of Health, RePORTER application 10599162, Genomics Shared Resource (5P30CA046934-35). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10599162. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*