ABSTRACT St. Jude Children's Research Hospital The Adolescent Medicine Trials Network for HIV/AIDS Interventions (ATN) aims over the 7-year funding cycle to develop and conduct innovative behavioral, community-based, translational, therapeutic, microbicide, and vaccine trials in youth ages 13-24 years at-risk for HIV and living with HIV, with a focus on the inclusion of minors. The ATN seeks investigators with innovative thinking and novel approaches to address the public health issues facing adolescents. The St. Jude Memphis Site Consortium (SMSC), based in Memphis located in the Shelby County of TN has (1) a well-established clinical and clinical research facility at St. Jude Children's Research Hospital (former ATN site), (2) A long-standing Connect to Protect Memphis Coalition (C2P Memphis) of over 25 stakeholders (Community Based organizations, Non for Profit Groups, Memphis Schools, etc.) invested in the interests of youth and (3) established partnerships including with academia (University of Tennessee) and the local Shelby County and Tennessee state health departments. Shelby County is an Ending the HIV Epidemic Priority jurisdiction. The SMSC closely collaborating with the Westat led ATN Operations and Collaborations Center (OCC) will participate in the development of clinical trials and provide the clinical research site(s), local laboratory capacity, and investigational pharmacy support to further the ATN Research agenda. Taking the clinical trials to youth at risk of HIV and those living with HIV who are not aware of their diagnosis will require using innovative approaches for recruitment which the SMSC has demonstrated in the past and looks forward to building on. The C2P Memphis Coalition and a separate youth community advisory board will over the project period be instrumental in providing input both for clinical trial design as well as youth engagement and retention approaches.