# Regenerating cranial suture (Jaylynn Jones)

> **NIH NIH R01** · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2022 · $76,304

## Abstract

ABSTRACT
Craniosynostosis is a debilitating congenic condition characterized by premature cranial suture fusion, resulting
in abnormal skull shape, blindness, and potential neurologic and/or developmental defects. The prevalence of
craniosynostosis is at approximately 1 in 2,500 live births, which is one of the highest incidences of congenital
malformations of the skeletal system. We have assembled a strong collaborative team combining Dr. Hatch’s
expertise in the mechanisms underlying coronal craniosynostosis and Dr. Mishina’s expertise in suture
development and midline craniosynostosis animal model along with experiences in 3D tissue engineering
scaffolds and biomolecule delivery for craniofacial tissue regeneration. In the parental grant, we have proposed
the following specific Aims: Aim 1, we will develop 3D scaffold-based microenvironment to maintain suture
mesenchymal stem cells; in Aim 2, we will establish 3D culture system to regenerate and maintain bone-
suture-bone tissue composite; in Aim 3, we will establish the efficacy of engineered scaffolds and controlled
release systems for preventing craniosynostosis in vivo. By accomplishing these specific aims, we have
developed a novel strategy to cure or diminish the severity and recurrence of craniosynostosis in humans,
hence significantly improving patient quality of life. During 3 and half years of the funding period of the parent
grant, we have made substantial progresses on the Aim 1 and Aim 2. We are currently putting more efforts
towards Aim 3 experiments, which requires development of a survival animal surgery model. Addition of Ms.
Jaylynn Jones will further accelerate our team efforts to propel our progress and enhance the diversity of our
interdisciplinary team, while providing her meaningful career development opportunity.

## Key facts

- **NIH application ID:** 10599728
- **Project number:** 3R01DE027662-05S1
- **Recipient organization:** UNIVERSITY OF MICHIGAN AT ANN ARBOR
- **Principal Investigator:** Nan E Hatch
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $76,304
- **Award type:** 3
- **Project period:** 2018-09-12 → 2023-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10599728

## Citation

> US National Institutes of Health, RePORTER application 10599728, Regenerating cranial suture (Jaylynn Jones) (3R01DE027662-05S1). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10599728. Licensed CC0.

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