# Investigations to Assess the Role of Glucagon Signaling in Healthspan and Aging

> **NIH NIH R00** · UNIVERSITY OF ARIZONA · 2022 · $119,976

## Abstract

Calorie restriction increases liver 5’AMP kinase (AMPK) activity. Like the glucagon receptor, AMPK is
essential for calorie restriction to extend lifespan and healthspan. Because AMPK is downstream of glucagon
receptor signaling it is possible that glucagon receptor activated AMPK is necessary for calorie restriction to
improve healthspan We propose that glucagon receptor signaling at the liver, which increases with both calorie
restriction and obesity, slows aging dependent upon glucagon receptor stimulated AMPK activity. The proposed
study will extend our findings from the parent grant to assess the ability to rescue the impaired healthspan in
glucagon receptor null mice by inducing hepatocyte expression of a constitutively active AMPK.

## Key facts

- **NIH application ID:** 10600274
- **Project number:** 3R00AG055649-05S1
- **Recipient organization:** UNIVERSITY OF ARIZONA
- **Principal Investigator:** JENNIFER HELENE STERN
- **Activity code:** R00 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $119,976
- **Award type:** 3
- **Project period:** 2017-08-15 → 2023-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10600274

## Citation

> US National Institutes of Health, RePORTER application 10600274, Investigations to Assess the Role of Glucagon Signaling in Healthspan and Aging (3R00AG055649-05S1). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10600274. Licensed CC0.

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