PROJECT The with with structural obtained harboring assessment clinical to diagnosis medicine' target SUMMARY current project titled “ A Functional Investigation of Structural Variants Associated Schizophrenia ” proposes the investigation of a class of genomic variants associated schizophrenia risk, `structural variants', using two approaches. First, t he function of variants will be investigated at the level of the brain, in post-mortem brain samples from patients with schizophrenia and normal healthy controls. Second, patients specific structural variants will be recruited for clinical evaluation, including an of behavior and cognition. This study will allow for the neurobiological and characterization of an important class of genomic variants that may be contributory schizophrenia risk. The proposed investigation has the potential to lead to improved of schizophrenia, as well as improved treatment options, through a `precision approach of stratifying patients by underlying genetic variants, to more effectively existing and novel therapeutics.