PROJECT SUMMARY In the US, approximately 1.5M babies are admitted to the Neonatal Intensive Care Unit (NICU) each year. Continuous monitoring of these patients is essential and the ability to quickly identify critical changes in a patients' health status is crucial to guiding daily care and therapy. While individual medical devices are helpful in this endeavor, integrating information from multiple devices onto one display and performing real-time analytics on this data enhances identification of the reasons for a change in patient condition and not just that a condition has changed. Continuously recording and providing both trending and real-time analysis for real changes in patient status can help optimize care decisions thus improving outcomes in this fragile population. In this grant we will build upon the success of the previously cleared Vital Sync multi-modal monitor that captures and analyzes information from over 100 devices in the NICU to help make the information actionable. The new device provides a continuous and retrospective view of patient condition so that care providers can objectively evaluate the effectiveness of treatment modifications. Real time assistance with identification of changes in patient condition helps to optimize new neuroprotective protocols. Improved review of prior patient condition through trending analysis and event marking assists with continuity of care across shift changes. The Phase I prototype is designed to evaluate the feasibility and usability of the tool in the NICU environment. The phase 2 system will support additional features including reduced connectivity burden and protocol support. Centraview 2.0 will be a platform for future modular upgrades that will enhance clinical decision support (CDS) in any ICU environment. Phase 1 Aim 1 – Create a prototype multimodal monitor for neonatal neurocritical care Based on existing experience and technology, we will design and prototype a new generation bedside monitoring system for collecting and displaying data from the key NICU medical devices at UFHealth. Phase 1 Aim 2 – Evaluate usability of the new system in a simulated NICU In a simulated NICU environment, we will create three neonatal patient scenarios and evaluate the system in a usability study with 8 NICU clinicians including surveys to determine perceived value, usability, and acceptance. Phase 2 Aim 1 – Expand connectivity, add protocol adherence, and enhance usability Clinical feedback from a successful Phase 1 will be used to improve the functionality and usability of CentraView 2. HIE protocol support will be added to the system along with several other new features including derived parameters and wireless data collection. Phase 2 – Aim 2 – Evaluate the effectiveness of CentraView 2 Clinical Assistant We will first collect baseline data for 6 months at UFHealth to measure adherence with several clinical practice guidelines (CPG). Next, we will install and train clinicians on the use of th...