# Groundwork for a Synchrotron MicroCT Imaging Resource for Biology (SMIRB)

> **NIH NIH R24** · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · 2022 · $231,489

## Abstract

Abstract
We request Alternation and Renovation supplementary funds to allow us to accomplish critical primary
goals of our project, Groundwork for a Synchrotron MicroCT Resource for Biology. The enabled work
will broaden understanding of the potential impact of this new technology across a variety of model
systems and experimental questions. Specifically, the funds would allow us to move into a new room
recently awarded by Penn State College of Medicine that will allow us to accommodate collaborative
computational space for personnel, as well as two microCT machines. The new “production” microCT
imaging system will create a way to continue scanning pilot samples for a range of collaborators while
we continue uninterrupted “developmental” work on the first system to increase field-of-view,
throughput, and image quality. The urgency for supplementary funds at this time is caused by the
recent receipt of a new 12 mm field-of-view system that greatly increases the types of samples that
can be imaged using our new technology – a system advance made possible by last year’s
supplement. In short, the pan-cellular, full volume nature of the 3D images will allow unprecedented
scope and depth of characterization of the diversity of life and tissue structure across all organisms. The
supplement will greatly increase our ability to advance the new field of spatial biology by creating new
microanatomic and anatomic anchors for other imaging modes such as immunohistochemistry,
immunofluorescence, and MRI, and for transcriptomics, proteomics, metabolomics and other
molecular “-omics” data.

## Key facts

- **NIH application ID:** 10601778
- **Project number:** 3R24OD018559-08S2
- **Recipient organization:** PENNSYLVANIA STATE UNIV HERSHEY MED CTR
- **Principal Investigator:** Keith Chi Cheng
- **Activity code:** R24 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $231,489
- **Award type:** 3
- **Project period:** 2015-08-15 → 2024-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10601778

## Citation

> US National Institutes of Health, RePORTER application 10601778, Groundwork for a Synchrotron MicroCT Imaging Resource for Biology (SMIRB) (3R24OD018559-08S2). Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/grant/nih/10601778. Licensed CC0.

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