# Core-001 - COPE Core B

> **NIH NIH P01** · UNIVERSITY OF CALIFORNIA, SAN DIEGO · 2023 · $468,711

## Abstract

Core B: Clinical, Outreach, Pathology and Ethics (COPE) Core - ABSTRACT
The Clinical, Outreach, Pathology and Ethics (COPE) Core’s mission is to ethically collect, store and provide
the biological specimens needed for the scientific aims of the HIV Obligate MicroEnvironment (HOME) program.
A highly innovative component of our program and the COPE Core is the peri-mortem translational research
model, ‘Last Gift’ cohort. The cohort is comprised of persons with HIV (PWH) who have a terminal illness, usually
from a non-AIDS related condition who wish to participate in HIV cure-related research before they die and
donate their entire bodies after death for rapid research autopsy. These participants will be recruited from
palliative care programs and clinics in San Diego that provide services to PWH.
The COPE Core will fulfill four specific aims:
Aim 1. Community Outreach: A critical and consistent component of the HOME project will be the involvement
of community partners in all phases of the program. We will continue robust community and stakeholder
engagement efforts to ensure acceptance and sustainability of the Last Gift cohort. This will consist of scheduled
activities with community advisory groups. We will also actively engage with local residential palliative care
programs that provide end-of-life care for PWH. We will also continue to engage with clinical and research
partners who are critical to the success of the program.
Aim 2. Support of the Last Gift cohort: This will include study recruitment, data collection, collection of pre-
mortem samples (e.g., genital secretions, cerebrospinal fluid, lymph node, adipose tissues and rectal biopsies),
body transport, rapid autopsy protocol and tissue processing for the HOME program.
Aim 3. Support of the Last Gift biorepository: External investigators will be able to access the Last Gift
biorepository through a concept sheet review process. The COPE Core will review and organize the collection
and processing of all specimens, as well as labeling, bar coding, transporting and cryostoring of specimens.
Aim 4: Ethics of end-of-life research: The COPE Core will engage an Ethics Oversight Committee (EOC) in
the review of all Last Gift protocols and community engagement activities. The EOC will evaluate ethical and
safety issues related to the program. The COPE Core will also conduct qualitative socio-behavioral and empirical
ethics research with Last Gift participants next-of-kin/loved ones, and clinical and rapid research autopsy staff to
ensure ethical conduct of research and patient/participant-centered approaches.

## Key facts

- **NIH application ID:** 10602740
- **Project number:** 5P01AI169609-02
- **Recipient organization:** UNIVERSITY OF CALIFORNIA, SAN DIEGO
- **Principal Investigator:** SUSAN JANET LITTLE
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2023
- **Award amount:** $468,711
- **Award type:** 5
- **Project period:** 2022-04-01 → 2027-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10602740

## Citation

> US National Institutes of Health, RePORTER application 10602740, Core-001 - COPE Core B (5P01AI169609-02). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10602740. Licensed CC0.

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