# 7T functional MRS of metabolite variations during working memory in subjects with post-traumatic stress disorder

> **NIH NIH K01** · AUBURN UNIVERSITY AT AUBURN · 2022 · $54,000

## Abstract

In response to NOT-MH-21-120 “Administrative Supplements for COVID-19 Impacted NIMH Research,” this
application seeks additional support for the principal investigator to complete the aims of the Mentored Research
Scientist Development Award number K01MH115272. The goal of the research project is to examine the neural
mechanisms that contribute to working memory deficits in people with posttraumatic stress disorder (PTSD).
This project combines 7T resting-state magnetic resonance spectroscopy (MRS), advanced dynamic functional
MRS (fMRS), and functional magnetic resonance imaging (fMRI) to investigate the relationship between
neurochemistry and brain activation during working memory in PTSD. The specific aims are to (1) measure
glutamate and other metabolites in the dorsolateral prefrontal cortex (DLPFC) of people with and without PTSD
using resting-state MRS; (2) investigate the relationship between resting-state levels of glutamate and functional
activation during the n-back working memory task in people with and without PTSD using MRS and fMRI; and
(3) characterize dynamic glutamate changes during working memory in people with and without PTSD using
fMRS during the n-back task. The PI has made substantial progress towards completing these aims. However,
the COVID-19 pandemic has caused significant delays in recruitment and data collection. In this application, we
request supplemental support for the PI to offset the loss of time due to COVID-19, complete enrollment of
human subjects, and fulfill the aims of the project.

## Key facts

- **NIH application ID:** 10603379
- **Project number:** 3K01MH115272-04S1
- **Recipient organization:** AUBURN UNIVERSITY AT AUBURN
- **Principal Investigator:** Meredith A Reid
- **Activity code:** K01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $54,000
- **Award type:** 3
- **Project period:** 2018-08-15 → 2023-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10603379

## Citation

> US National Institutes of Health, RePORTER application 10603379, 7T functional MRS of metabolite variations during working memory in subjects with post-traumatic stress disorder (3K01MH115272-04S1). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10603379. Licensed CC0.

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