# Thalamocortical mechanisms producing spatial chromatic contrast in mouse V1

> **NIH NIH F30** · UNIVERSITY OF COLORADO DENVER · 2023 · $36,124

## Abstract

PROJECT SUMMARY
The ability to integrate color and form into coherent visual scenes is an important part of our interactions with
the environment. This ability is impaired in many ophthalmologic and neuropsychiatric disorders, yet the neural
mechanisms responsible for visual feature integration remain understudied. The use of mice as a model
organism has provided deep insights into fundamental mechanisms of vison conserved across species and
general principles of neural information processing. Recent work in mice has shown that the early mouse
visual system is wired to respond to chromatic information and mice can use this information to guide behavior.
However, it is unclear how the early visual system integrates spectral and luminance contrasts to represent
color spatially. My own preliminary data has demonstrated that neurons in mouse primary visual cortex (V1)
can respond to spatial luminance contrast (i.e., form) in a color-dependent manner, building on work
demonstrating responses to color contrast in in the lateral geniculate nucleus of the thalamus (LGN) – the
preceding stage of visual hierarchy. This suggests that color and form begin their integration through
thalamocortical networks, though the exact mechanism of integration is unknown.
 Thus, the goal of this proposal is to ask how, neurally, are variations in color and luminance integrated
to generate spatial chromatic contrast? To do this, I will need to measure responses from a large number of
neurons in LGN and V1 to capture the breadth of chromatic responses and relevant connections between
regions. Leveraging the relative scale of the mouse visual system and high-density electrophysiology, this
project will examine mechanisms of spatial chromatic integration with a high degree of spatiotemporal
resolution. Aim 1 will examine the functional convergence of chromatic and achromatic signals from LGN to
produce chromatic selectivity in V1. Aim 2 will then examine if and how intracortical networks enhance
chromatic selectivity to refine color tuning for subsequent stages of visual processing.
 In sum, this proposal will expand our fundamental understanding of how the early visual system
integrates color and luminance spatially, providing a steppingstone to further experiments investigating how
color integrates with specific visual features such as orientation, direction, motion, and ultimately how color is
integrated into complex naturalistic scenes. This work will also provide the applicant with invaluable training in
his future career as a neuropsychiatrist focused on translating foundational knowledge from computational
neuroscience into novel, highly precise therapeutics.

## Key facts

- **NIH application ID:** 10604752
- **Project number:** 1F30EY034775-01
- **Recipient organization:** UNIVERSITY OF COLORADO DENVER
- **Principal Investigator:** Juan Gabriel Santiago Moreno
- **Activity code:** F30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2023
- **Award amount:** $36,124
- **Award type:** 1
- **Project period:** 2023-01-01 → 2026-12-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10604752

## Citation

> US National Institutes of Health, RePORTER application 10604752, Thalamocortical mechanisms producing spatial chromatic contrast in mouse V1 (1F30EY034775-01). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10604752. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*